Lower brainstem mechanisms of body temperature regulation in the guinea-pig (Cavia aperea porcellus)

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Abstract

1. 1.|Thermophysiological and electrophysiological data have indicated that in the guinea-pig the ponto-medullary area contains structures with specific functions in temperature regulation. 2. 2.|An ascending noradrenergic mechanism has been demonstrated in the lower brainstem, the activation of which results in a thermogenic response via an alpha-adrenergic mechanism in the hypothalamus. The subcoeruleus area was found to be an important source of this ascending pathway. 3. 3.|Electrical stimulation of the subcoeruleus area inhibited warm-responsive hypothalamic units; the areas was shown to receive thermal afferents from the skin. 4. 4.|The nucleus raphe magnus was demonstrated to receive afferents mainly from warm-sensitive skin sites and its stimulation inhibited cold-responsive hypothalamic units. Electrical stimulation of the nucleus raphe magnus inhibited cold-induced thermogenesis. 5. 5.|Lesioning the same raphe nucleus improved the cold- and heat-defence of guinea-pigs and resulted in a more precise regulation of body temperature.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalJournal of Thermal Biology
Volume11
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

Body Temperature Regulation
brain stem
thermoregulation
guinea pigs
Brain Stem
Skin
Guinea Pigs
Electric Stimulation
Hot Temperature
Adrenergic Agents
heat
Raphe Nuclei
Thermogenesis
Chemical activation
hypothalamus
heat production
Temperature
Hypothalamus
temperature
Nucleus Raphe Magnus

Keywords

  • heat loss effectors
  • heat production effectors
  • lower brainstem
  • nucleus raphe magnus
  • subcoeruleus area
  • Temperature regulation
  • thermoafferent systems

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

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title = "Lower brainstem mechanisms of body temperature regulation in the guinea-pig (Cavia aperea porcellus)",
abstract = "1. 1.|Thermophysiological and electrophysiological data have indicated that in the guinea-pig the ponto-medullary area contains structures with specific functions in temperature regulation. 2. 2.|An ascending noradrenergic mechanism has been demonstrated in the lower brainstem, the activation of which results in a thermogenic response via an alpha-adrenergic mechanism in the hypothalamus. The subcoeruleus area was found to be an important source of this ascending pathway. 3. 3.|Electrical stimulation of the subcoeruleus area inhibited warm-responsive hypothalamic units; the areas was shown to receive thermal afferents from the skin. 4. 4.|The nucleus raphe magnus was demonstrated to receive afferents mainly from warm-sensitive skin sites and its stimulation inhibited cold-responsive hypothalamic units. Electrical stimulation of the nucleus raphe magnus inhibited cold-induced thermogenesis. 5. 5.|Lesioning the same raphe nucleus improved the cold- and heat-defence of guinea-pigs and resulted in a more precise regulation of body temperature.",
keywords = "heat loss effectors, heat production effectors, lower brainstem, nucleus raphe magnus, subcoeruleus area, Temperature regulation, thermoafferent systems",
author = "Zolt{\'a}n Szel{\'e}nyi",
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AU - Szelényi, Zoltán

PY - 1986

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N2 - 1. 1.|Thermophysiological and electrophysiological data have indicated that in the guinea-pig the ponto-medullary area contains structures with specific functions in temperature regulation. 2. 2.|An ascending noradrenergic mechanism has been demonstrated in the lower brainstem, the activation of which results in a thermogenic response via an alpha-adrenergic mechanism in the hypothalamus. The subcoeruleus area was found to be an important source of this ascending pathway. 3. 3.|Electrical stimulation of the subcoeruleus area inhibited warm-responsive hypothalamic units; the areas was shown to receive thermal afferents from the skin. 4. 4.|The nucleus raphe magnus was demonstrated to receive afferents mainly from warm-sensitive skin sites and its stimulation inhibited cold-responsive hypothalamic units. Electrical stimulation of the nucleus raphe magnus inhibited cold-induced thermogenesis. 5. 5.|Lesioning the same raphe nucleus improved the cold- and heat-defence of guinea-pigs and resulted in a more precise regulation of body temperature.

AB - 1. 1.|Thermophysiological and electrophysiological data have indicated that in the guinea-pig the ponto-medullary area contains structures with specific functions in temperature regulation. 2. 2.|An ascending noradrenergic mechanism has been demonstrated in the lower brainstem, the activation of which results in a thermogenic response via an alpha-adrenergic mechanism in the hypothalamus. The subcoeruleus area was found to be an important source of this ascending pathway. 3. 3.|Electrical stimulation of the subcoeruleus area inhibited warm-responsive hypothalamic units; the areas was shown to receive thermal afferents from the skin. 4. 4.|The nucleus raphe magnus was demonstrated to receive afferents mainly from warm-sensitive skin sites and its stimulation inhibited cold-responsive hypothalamic units. Electrical stimulation of the nucleus raphe magnus inhibited cold-induced thermogenesis. 5. 5.|Lesioning the same raphe nucleus improved the cold- and heat-defence of guinea-pigs and resulted in a more precise regulation of body temperature.

KW - heat loss effectors

KW - heat production effectors

KW - lower brainstem

KW - nucleus raphe magnus

KW - subcoeruleus area

KW - Temperature regulation

KW - thermoafferent systems

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