Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study

M. R. Laurent, M. J. Cook, E. Gielen, K. A. Ward, L. Antonio, J. E. Adams, B. Decallonne, G. Bártfai, F. F. Casanueva, G. Forti, A. Giwercman, I. T. Huhtaniemi, K. Kula, M. E J Lean, D. M. Lee, N. Pendleton, M. Punab, F. Claessens, F. C W Wu, D. VanderschuerenS. R. Pye, T. W. O’Neill, Group Emas Group

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40–79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). Results: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P < 0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P ≤ 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and β-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress–strain index. HOMA-S was similarly associated with PINP and β-CTX, BUA, and radius CSA in BMI-adjusted models. Conclusions: Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone’s failure to adapt to increasing bodily loads in men with MetS.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalOsteoporosis International
DOIs
Publication statusAccepted/In press - Jun 7 2016

Fingerprint

Bone Remodeling
Insulin Resistance
Bone and Bones
Hypertriglyceridemia
Hyperglycemia
Hip
Body Mass Index
Heel
Femur Neck
Bone Density
Linear Models
Spine
Osteocalcin
Collagen Type I
Obesity
Smoking
Tomography
Alcohols

Keywords

  • Bone mineral density
  • Bone turnover
  • Male
  • Metabolic syndrome
  • Obesity
  • Peripheral quantitative computed tomography

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Lower bone turnover and relative bone deficits in men with metabolic syndrome : a matter of insulin sensitivity? The European Male Ageing Study. / Laurent, M. R.; Cook, M. J.; Gielen, E.; Ward, K. A.; Antonio, L.; Adams, J. E.; Decallonne, B.; Bártfai, G.; Casanueva, F. F.; Forti, G.; Giwercman, A.; Huhtaniemi, I. T.; Kula, K.; Lean, M. E J; Lee, D. M.; Pendleton, N.; Punab, M.; Claessens, F.; Wu, F. C W; Vanderschueren, D.; Pye, S. R.; O’Neill, T. W.; Emas Group, Group.

In: Osteoporosis International, 07.06.2016, p. 1-11.

Research output: Contribution to journalArticle

Laurent, MR, Cook, MJ, Gielen, E, Ward, KA, Antonio, L, Adams, JE, Decallonne, B, Bártfai, G, Casanueva, FF, Forti, G, Giwercman, A, Huhtaniemi, IT, Kula, K, Lean, MEJ, Lee, DM, Pendleton, N, Punab, M, Claessens, F, Wu, FCW, Vanderschueren, D, Pye, SR, O’Neill, TW & Emas Group, G 2016, 'Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study', Osteoporosis International, pp. 1-11. https://doi.org/10.1007/s00198-016-3656-x
Laurent, M. R. ; Cook, M. J. ; Gielen, E. ; Ward, K. A. ; Antonio, L. ; Adams, J. E. ; Decallonne, B. ; Bártfai, G. ; Casanueva, F. F. ; Forti, G. ; Giwercman, A. ; Huhtaniemi, I. T. ; Kula, K. ; Lean, M. E J ; Lee, D. M. ; Pendleton, N. ; Punab, M. ; Claessens, F. ; Wu, F. C W ; Vanderschueren, D. ; Pye, S. R. ; O’Neill, T. W. ; Emas Group, Group. / Lower bone turnover and relative bone deficits in men with metabolic syndrome : a matter of insulin sensitivity? The European Male Ageing Study. In: Osteoporosis International. 2016 ; pp. 1-11.
@article{3a0befff15454a62a5926e25f5f68307,
title = "Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study",
abstract = "Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40–79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). Results: MetS was present in 975 men (31.2 {\%}). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P < 0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P ≤ 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and β-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress–strain index. HOMA-S was similarly associated with PINP and β-CTX, BUA, and radius CSA in BMI-adjusted models. Conclusions: Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone’s failure to adapt to increasing bodily loads in men with MetS.",
keywords = "Bone mineral density, Bone turnover, Male, Metabolic syndrome, Obesity, Peripheral quantitative computed tomography",
author = "Laurent, {M. R.} and Cook, {M. J.} and E. Gielen and Ward, {K. A.} and L. Antonio and Adams, {J. E.} and B. Decallonne and G. B{\'a}rtfai and Casanueva, {F. F.} and G. Forti and A. Giwercman and Huhtaniemi, {I. T.} and K. Kula and Lean, {M. E J} and Lee, {D. M.} and N. Pendleton and M. Punab and F. Claessens and Wu, {F. C W} and D. Vanderschueren and Pye, {S. R.} and O’Neill, {T. W.} and {Emas Group}, Group",
year = "2016",
month = "6",
day = "7",
doi = "10.1007/s00198-016-3656-x",
language = "English",
pages = "1--11",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",

}

TY - JOUR

T1 - Lower bone turnover and relative bone deficits in men with metabolic syndrome

T2 - a matter of insulin sensitivity? The European Male Ageing Study

AU - Laurent, M. R.

AU - Cook, M. J.

AU - Gielen, E.

AU - Ward, K. A.

AU - Antonio, L.

AU - Adams, J. E.

AU - Decallonne, B.

AU - Bártfai, G.

AU - Casanueva, F. F.

AU - Forti, G.

AU - Giwercman, A.

AU - Huhtaniemi, I. T.

AU - Kula, K.

AU - Lean, M. E J

AU - Lee, D. M.

AU - Pendleton, N.

AU - Punab, M.

AU - Claessens, F.

AU - Wu, F. C W

AU - Vanderschueren, D.

AU - Pye, S. R.

AU - O’Neill, T. W.

AU - Emas Group, Group

PY - 2016/6/7

Y1 - 2016/6/7

N2 - Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40–79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). Results: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P < 0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P ≤ 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and β-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress–strain index. HOMA-S was similarly associated with PINP and β-CTX, BUA, and radius CSA in BMI-adjusted models. Conclusions: Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone’s failure to adapt to increasing bodily loads in men with MetS.

AB - Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40–79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). Results: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P < 0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P ≤ 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and β-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress–strain index. HOMA-S was similarly associated with PINP and β-CTX, BUA, and radius CSA in BMI-adjusted models. Conclusions: Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone’s failure to adapt to increasing bodily loads in men with MetS.

KW - Bone mineral density

KW - Bone turnover

KW - Male

KW - Metabolic syndrome

KW - Obesity

KW - Peripheral quantitative computed tomography

UR - http://www.scopus.com/inward/record.url?scp=84976309693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976309693&partnerID=8YFLogxK

U2 - 10.1007/s00198-016-3656-x

DO - 10.1007/s00198-016-3656-x

M3 - Article

C2 - 27273111

AN - SCOPUS:84976309693

SP - 1

EP - 11

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

ER -