Low serum dopamine-beta-hydroxylase activity in human obesity

L. Halmy, G. Bagdy, C. Nyakas

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1 Citation (Scopus)


The activity of dopamine-beta-hydroxylase (DBH) is under strict genetic control in man. The serum level of DBH activity was measured in obese patients in order to establish if there is any characteristic range in DBH activity in this population. The patients, aged between 23-58 years, were normotensive and had no endocrine diseases. In both sexes the obese patients showed considerably lower DBH activity than controls. The means ± SE in obese men were 18.55 ± 1.57/ 64%, p <0.01/ vs. control value of 29.19 ± 3.06; in obese women 22.02 ± 2.46 / 57%, p <0.001/ vs. control value of 38.51 ± 3.62 expressed in μmol/min/l. The results indicate that the low serum DBH activity and the disposition to obesity are genetically related phenomena, and that the low activity of DBH in serum might be one of the indicators of decreased sympathetic tone of the autonomic nervous system.

Original languageEnglish
Number of pages1
JournalIRCS Medical Science
Issue number1
Publication statusPublished - Jan 1 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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