Low serum adiponectin predicts 10-year risk of type 2 diabetes and hba1c independently of obesity, lipids, and inflammation: Whitehall II study

A. G. Tabák, E. J. Brunner, M. A. Miller, S. Karanam, P. G. McTernan, F. P. Cappuccio, D. R. Witte

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Abstract

Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n=140) of the Whitehall II Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5±3.0 years). Adiponectin levels were lower among cases (9.3g/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1g/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.

Original languageEnglish
Pages (from-to)626-629
Number of pages4
JournalHormone and Metabolic Research
Volume41
Issue number8
DOIs
Publication statusPublished - Nov 2 2009

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Keywords

  • Adipokines
  • C-reactive protein
  • Follow-up studies
  • Glycosylated
  • Haemoglobin A

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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