Low-power composite CPMG HSQMBC experiment for accurate measurement of long-range heteronuclear coupling constants

Sándor Boros, Katalin E. Kövér

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A modified version of CPMG-HSQMBC pulse scheme is presented for the measurement of long-range heteronuclear coupling constants. The method implements adiabatic inversion and refocusing pulses on the heteronucleus. Low-power composite 180° XY-16 CPMG pulse train is applied on both proton and X nuclei during the evolution of long-range couplings to eliminate phase distortions due to co-evolution of homonuclear proton-proton couplings. The pulse sequence yields pure absorption antiphase multiplets allowing precise and direct measurement of the nJXH coupling constants regardless from the size of the proton-proton couplings. The applicability of the method is demonstrated using strychnine as a model compound. The selective 1D version of the method is also presented.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalMagnetic Resonance in Chemistry
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

Keywords

  • HSQMBC
  • NMR
  • XY-16 CPMG
  • long-range heteronuclear coupling constants
  • low-power composite pulses
  • strychnine

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

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