Low occurrence of the HLA-C*04

09N allele in a large Hungarian cohort

A. Bors, D. Inotai, H. Andrikovics, S. Benko, A. Boros-Major, Z. Illés, A. Szilvási, A. Gelle-Hossó, K. Rajczy, A. Tordai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The presence of null alleles may affect the outcome of stem cell transplantation. HLA-C*04:09N was defined as 'common' with a frequency of 2-5/1000 in Caucasians, and its presence is routinely tested as part of haplotypes HLA-A*02:01/A*23:01-B*44:03-DRB1*07:01-DQB1*02:01. We aimed to investigate HLA-C*04:09N in a representative Hungarian cohort. HLA-typing data of 7345 unrelated persons were analyzed. The presence of HLA-C*04:09N was excluded in 157 chromosomes with either serology typing or with an allele-specific polymerase chain reaction for HLA-C*04:09N. HLA-C*04:09N was identified in a single chromosome with HLA-A*02, B*44, C*04, DRB1*07 resulting in a HLA-C*04:09N allele frequency of 0.0068% (1/14,690). This is approximately a 10- to 40-fold lower frequency compared with the previous data. Our results emphasize the need of precise local population-specific HLA-data, allowing appropriate modifications of local HLA-typing protocols.

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalTissue Antigens
Volume86
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

HLA-C Antigens
Alleles
Histocompatibility Testing
HLA-A Antigens
Chromosomes
Stem Cell Transplantation
Serology
Gene Frequency
Haplotypes
Polymerase Chain Reaction
Population

Keywords

  • 04:09N
  • Common haplotype
  • HLA-C
  • HLA-typing
  • Hungarian population
  • Null-allele

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

Low occurrence of the HLA-C*04 : 09N allele in a large Hungarian cohort. / Bors, A.; Inotai, D.; Andrikovics, H.; Benko, S.; Boros-Major, A.; Illés, Z.; Szilvási, A.; Gelle-Hossó, A.; Rajczy, K.; Tordai, A.

In: Tissue Antigens, Vol. 86, No. 1, 01.07.2015, p. 32-35.

Research output: Contribution to journalArticle

Bors, A, Inotai, D, Andrikovics, H, Benko, S, Boros-Major, A, Illés, Z, Szilvási, A, Gelle-Hossó, A, Rajczy, K & Tordai, A 2015, 'Low occurrence of the HLA-C*04: 09N allele in a large Hungarian cohort', Tissue Antigens, vol. 86, no. 1, pp. 32-35. https://doi.org/10.1111/tan.12587
Bors, A. ; Inotai, D. ; Andrikovics, H. ; Benko, S. ; Boros-Major, A. ; Illés, Z. ; Szilvási, A. ; Gelle-Hossó, A. ; Rajczy, K. ; Tordai, A. / Low occurrence of the HLA-C*04 : 09N allele in a large Hungarian cohort. In: Tissue Antigens. 2015 ; Vol. 86, No. 1. pp. 32-35.
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