Low mannose-binding lectin (MBL) is associated with paediatric inflammatory bowel diseases and ileal involvement in patients with Crohn disease

Marta Kovacs, Maria Papp, Peter Laszlo Lakatos, Silvia Jacobsen, Eva Nemes, Marianne Polgar, Eniko Solyom, Piroska Bodi, Agnes Horvath, Kriszta Molnar, Doloresz Szabo, Aron Cseh, Katalin Eszter Muller, Antal Dezsofi, Andras Arato, Gabor Veres

Research output: Contribution to journalArticle

7 Citations (Scopus)


Background: Mannose-binding lectin (MBL) is a pattern-recognition molecule of the innate immune system and may be involved in the pathogenesis of inflammatory bowel disease (IBD). Our aim was to assess the prevalence of MBL deficiency in a cohort of patients with paediatric-onset IBD and study whether it is associated with the clinical manifestations, serum antibody formation, or genetic factors. Methods: This prospective study included 159 paediatric patients (mean age: 14.0. years) with IBD [107 patients with Crohn disease (CD) and 52 patients with ulcerative colitis (UC)]. Furthermore, 95 controls were investigated. Serum samples were determined for MBL by enzyme-linked immunosorbent assay (ELISA) and for serologic markers [autoantibodies against Saccharomyces cerevisiae (ASCA) and perinuclear components of neutrophils (pANCA)] by indirect immunofluorescent assay. NOD2/CARD15 variants were tested by polymerase chain reaction/restriction fragment length polymorphism. Results: The MBL serum concentration was significantly lower in IBD patients(both with CD and UC) compared to controls (IBD, p = 0.007, CD, p = 0.04, UC p = 0.004). Prevalence of low MBL level (< 500. ng/mL) was significantly higher in both CD and UC groups compared to controls (p = 0.002 and p = 0.006). Furthermore, low MBL level was associated with isolated ileal involvement (p = 0.01) and MBL deficiency (< 100. ng/mL) with male gender (p = 0.004) in patients with CD. We failed to confirm any correlation between MBL deficiency and serum autoantibodies or NOD2/CARD15 variants. Conclusions: Our results suggest that low MBL associated with paediatric-onset IBD and ileal CD may be considered an additional marker of the IBD pathogenesis.

Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalJournal of Crohn's and Colitis
Issue number2
Publication statusPublished - Mar 1 2013


  • Crohn disease
  • Inflammatory bowel disease
  • MBL deficiency
  • Mannose-binding lectin (MBL)
  • Paediatric
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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