Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer

Florian Oehme, Stefan Krahl, Balazs Gyorffy, Benjamin Muessle, Venkatesh Rao, Helena Greif, Nicole Ziegler, Kuailu Lin, May Linn Thepkaysone, Heike Polster, Torsten Tonn, Martin Schneider, Juergen Weitz, Franziska Baenke, Christoph Kahlert

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69–11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time.

Original languageEnglish
Pages (from-to)1339-1345
Number of pages7
JournalRNA Biology
Volume16
Issue number10
DOIs
Publication statusPublished - Oct 3 2019

Keywords

  • Exosomes
  • colorectal cancer
  • diagnosis
  • liquid biopsy
  • long non-coding RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Oehme, F., Krahl, S., Gyorffy, B., Muessle, B., Rao, V., Greif, H., Ziegler, N., Lin, K., Thepkaysone, M. L., Polster, H., Tonn, T., Schneider, M., Weitz, J., Baenke, F., & Kahlert, C. (2019). Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer. RNA Biology, 16(10), 1339-1345. https://doi.org/10.1080/15476286.2019.1637697