Low level of cyclin D1 protein expression in thyroid microcarcinomas from an autopsy series

Gabor Laszlo Kovacs, Eva Stelkovics, Laszlo Krenacs, Gabor Gonda, Miklos Goth, Laszlo Kovacs, Zoltan Gorombey, Erika Hubina, Istvan Szabolcs

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3 Citations (Scopus)

Abstract

In a recent epidemiological screening study in an autopsy series, we found a high prevalence of microcarcinomas (MCs) (21/443 = 4.74%). We found no iodine intake-, gender-, or age-dependent differences in the prevalence of MCs. The results suggest a different and benign behavior of MCs compared to clinical cancer. The role of cyclin D1 overexpression in the pathogenesis of thyroid tumors is not known clearly; however, overexpression of this protein was reported in well-differentiated papillary cancers and in incidentally found metastasizing MCs. To date, cyclin D1 expression has not been investigated in autopsy-derived thyroid MCs. Eight MCs were available for immunostaining and comparison with 15 clinically detected papillary thyroid cancers. Fourteen out of 15 clinical carcinomas expressed cyclin D1 (93.3%), while in the MCs this ratio was 1 out of 8 (12.5%) (p = 0.0001). The only cyclin D1-positive MC was multifocal (both lobes of the gland were affected). We concluded that the benign behavior of most autopsyderived MCs may be associated with the lack of cyclin D1 overexpression.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalEndocrine
Volume26
Issue number1
Publication statusPublished - Feb 1 2005

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Keywords

  • Autopsy
  • Cyclin D1 expression
  • Immunohistochemistry
  • Thyroid microcarcinoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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