Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome

Ákos Várnagy, József Bódis, Zóltan Mánfai, Ferenc Wilhelm, Csaba Busznyák, Miklós Koppán

Research output: Contribution to journalArticle

45 Citations (Scopus)


Objective: To evaluate the effect of low-dose aspirin therapy on ovarian hyperstimulation syndrome (OHSS) in an unselected group of patients undergoing in vitro fertilization (IVF). Design: Randomized clinical trial. Setting: Division of Reproductive Medicine at the Department of Obstetrics and Gynecology, University of Pécs, Faculty of Medicine, Pécs, Hungary. Patient(s): Patients who underwent IVF between 2000 and 2006. Intervention(s): Initiation of 3154 IVF cycles, for which gonadotropin-releasing hormone agonist was used in 2425 cycles; 1503 cycles randomly selected for low-dose aspirin treatment starting from the first day of controlled ovarian hyperstimulation compared with no treatment in the remaining 922 cycles. Main Outcome Measure(s): The incidence of severe or critical OHSS and the rate of clinical pregnancy. Result(s): During this time period, 45 cases of severe OHSS were detected. Only two of the OHSS patients had received aspirin previously. Conclusion(s): Based on our preliminary results, introduction of low-dose aspirin therapy during ovulation induction for the prevention of OHSS in high-risk patients should be considered.

Original languageEnglish
Pages (from-to)2281-2284
Number of pages4
JournalFertility and Sterility
Issue number7
Publication statusPublished - May 1 2010


  • IVF
  • Low-dose aspirin
  • Ovarian hyperstimulation syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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