A psychosis szempontjából nagy kockázatú mentális állapotok és kezelésük: Elso hazai eredmények

Translated title of the contribution: Low dose antipsychotic treatment reduces the risk of progression to psychosis in persons with prodromal symptoms: Results from Hungary

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Recent evidence raised the possibility that row-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis. Aims: To investigate the effectiveness of low-dose antipsychotic medication in the prevention of psychosis. Methods: Fifty-two persons who fulfilled the PACE (Personal Assessment and Crisis Evaluation) criteria of ultra-high risk for psychosis participated in the study. Low-dose antipsychotic treatment (haloperidol or risperidone, 0.5-2 mg/day) was provided for 6 months together with psychoeducation and supportive psychotherapy. Participants were assessed at baseline, 6 months, and 12 months. Antidepressive therapy was provided as needed. Results: Forty-two persons completed the study from whom 3 (7.1 %) developed schizophrenia during the 6-month treatment period. New psychotic episodes were not observed during the 6-month follow-up period. Side effects were mild and transient, appearing in the first 4 weeks of treatment. The participants were satisfied with the treatment. Conclusions: Given that without a specific treatment, 30-60% of persons with ultra-high risk develop frank psychosis, low-dose antipsychotic treatment seems to be effective in the prevention or delay of psychosis.

Translated title of the contributionLow dose antipsychotic treatment reduces the risk of progression to psychosis in persons with prodromal symptoms: Results from Hungary
Original languageHungarian
Pages (from-to)201-204
Number of pages4
JournalOrvosi hetilap
Volume147
Issue number5
Publication statusPublished - Feb 5 2006

ASJC Scopus subject areas

  • Medicine(all)

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