Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept

E. Hrabovszky, Máté T. Sipos, Csilla S. Molnár, Philippe Ciofi, Beáta Á Borsay, Péter Gergely, László Herczeg, Stephen R. Bloom, Mohammad A. Ghatei, Waljit S. Dhillo, Z. Liposits

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis for the KP/NKB/DYN (KNDy) neuron concept; in both sexes, KNDy neuropeptides have been implicated in the generation of GnRH neurosecretory pulses and in the negative feedback effects of sexual steroids to the reproductive axis. To test the validity and limitations of the KNDy neuron concept in the human, we carried out the comparative immunohistochemical analysis of the three neuropeptides in the infundibular nucleus (Inf; also known as arcuate nucleus) and stalk of young male human individuals (

Original languageEnglish
Pages (from-to)4978-4989
Number of pages12
JournalEndocrinology
Volume153
Issue number10
DOIs
Publication statusPublished - Oct 1 2012

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Neurokinin B
Kisspeptins
Dynorphins
Arcuate Nucleus of Hypothalamus
Neuropeptides
Neurons
Goats
Gonadotropin-Releasing Hormone
In Situ Hybridization
Rodentia
Sheep
Steroids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. / Hrabovszky, E.; Sipos, Máté T.; Molnár, Csilla S.; Ciofi, Philippe; Borsay, Beáta Á; Gergely, Péter; Herczeg, László; Bloom, Stephen R.; Ghatei, Mohammad A.; Dhillo, Waljit S.; Liposits, Z.

In: Endocrinology, Vol. 153, No. 10, 01.10.2012, p. 4978-4989.

Research output: Contribution to journalArticle

Hrabovszky, E. ; Sipos, Máté T. ; Molnár, Csilla S. ; Ciofi, Philippe ; Borsay, Beáta Á ; Gergely, Péter ; Herczeg, László ; Bloom, Stephen R. ; Ghatei, Mohammad A. ; Dhillo, Waljit S. ; Liposits, Z. / Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. In: Endocrinology. 2012 ; Vol. 153, No. 10. pp. 4978-4989.
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