Low C1-inhibitor levels predict early restenosis after eversion carotid endarterectomy

G. Széplaki, L. Varga, Judit Laki, Edit Dósa, Szabolcs Rugonfalvi-Kiss, Hans O. Madsen, Z. Prohászka, Andrea Kocsis, P. Gál, Attila Szabó, G. Acsády, I. Karádi, L. Selmeci, Peter Garred, G. Füst, L. Entz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE - Homozygotes for the normal (A) allele of mannose-binding lectin (MBL2) gene have higher risks to develop an early restenosis after eversion carotid endarterectomy (CEA). Activation of the lectin pathway is regulated by C1-inhibitor (C1-INH). The objective of the present study was to determine the predictive value of C1-INH in restenosis after CEA. METHODS AND RESULTS - C1-INH and MBL-associated serine protease-2 (MASP-2) were determined in samples serially taken from 64 patients with CEA, who were followed-up with carotid duplex scan (CDS) examinations for 14 months. MBL2 genotypes were also determined. Patients with >50% restenosis had lower C1-INH levels at 6 weeks (P=0.0052) and at 4 days (P=0.0277) postsurgery. C1-INH levels at 6 weeks correlated inversely with the CDS values at 14 months (r=-0.3415, P=0.0058), but only in MBL2 A/A homozygotes (r=-0.5044, P=0.0015). Patients with low C1-INH levels (C1-INH

Original languageEnglish
Pages (from-to)2756-2762
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2007

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Carotid Endarterectomy
Homozygote
Mannose-Binding Protein-Associated Serine Proteases
Mannose-Binding Lectin
Lectins
Alleles
Genotype
Genes

Keywords

  • Carotid arteries
  • Genetics
  • Inflammation
  • Restenosis
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Low C1-inhibitor levels predict early restenosis after eversion carotid endarterectomy. / Széplaki, G.; Varga, L.; Laki, Judit; Dósa, Edit; Rugonfalvi-Kiss, Szabolcs; Madsen, Hans O.; Prohászka, Z.; Kocsis, Andrea; Gál, P.; Szabó, Attila; Acsády, G.; Karádi, I.; Selmeci, L.; Garred, Peter; Füst, G.; Entz, L.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, No. 12, 12.2007, p. 2756-2762.

Research output: Contribution to journalArticle

Széplaki, G. ; Varga, L. ; Laki, Judit ; Dósa, Edit ; Rugonfalvi-Kiss, Szabolcs ; Madsen, Hans O. ; Prohászka, Z. ; Kocsis, Andrea ; Gál, P. ; Szabó, Attila ; Acsády, G. ; Karádi, I. ; Selmeci, L. ; Garred, Peter ; Füst, G. ; Entz, L. / Low C1-inhibitor levels predict early restenosis after eversion carotid endarterectomy. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2007 ; Vol. 27, No. 12. pp. 2756-2762.
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AU - Laki, Judit

AU - Dósa, Edit

AU - Rugonfalvi-Kiss, Szabolcs

AU - Madsen, Hans O.

AU - Prohászka, Z.

AU - Kocsis, Andrea

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AU - Szabó, Attila

AU - Acsády, G.

AU - Karádi, I.

AU - Selmeci, L.

AU - Garred, Peter

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AU - Entz, L.

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