Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen

Ágnes Gyetvai, Tamás Emri, Krisztina Takács, Tímea Dergez, Andrea Fekete, Miklós Pesti, István Pócsi, Béla Lenkey

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast→pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans.

Original languageEnglish
Pages (from-to)1140-1148
Number of pages9
JournalFEMS Yeast Research
Volume6
Issue number8
DOIs
Publication statusPublished - Dec 1 2006

Keywords

  • Apoptosis
  • Candida albicans
  • Candidiasis
  • Chemotherapy
  • Lovastatin
  • Pseudomycelium

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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