Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma

Csaba Forster-Horváth, Balázs Döme, Sándor Paku, Andrea Ladányi, Beáta Somlai, Sirpa Jalkanen, József Tímár

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20 Citations (Scopus)

Abstract

Intratumoral vessels are different both structurally and phenotypically, and this may have clinical significance. In this study we analysed the expression of an adhesion molecule - vascular adhesion protein-1 (VAP-1) - in melanoma-associated blood vessels in 28 primary skin melanoma cases using immunocytochemistry and immunoelectron microscopy. We have found that VAP-1 protein expression is significantly decreased in intratumoral vessels compared with peritumoral ones; this difference was independent of the tumour thickness. Loss of VAP-1 protein expression occurred in both endothelial and smooth muscle cell components. Unlike in other cancer types, the VAP-1 protein expression of intratumoral vessels did not correlate with the density of cytotoxic T-lymphocytes or dendritic cells. On the other hand, the 5-year survival of melanoma patients with low VAP-1 protein expression in intratumoral blood vessels (≤ 25%) was lower (26.3%) than in patients whose VAP-1 expression was higher (42.6%, P=0.0632). These results support the idea that the phenotype of intratumoral blood vessels is important in the progression of malignant melanoma.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalMelanoma research
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 1 2004

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Keywords

  • Intratumoral vessels
  • Melanoma
  • Survival
  • Vascular adhesion protein-1

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research

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