Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma

Csaba Forster-Horváth, B. Döme, S. Paku, A. Ladányi, B. Somlai, Sirpa Jalkanen, J. Tímár

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Intratumoral vessels are different both structurally and phenotypically, and this may have clinical significance. In this study we analysed the expression of an adhesion molecule - vascular adhesion protein-1 (VAP-1) - in melanoma-associated blood vessels in 28 primary skin melanoma cases using immunocytochemistry and immunoelectron microscopy. We have found that VAP-1 protein expression is significantly decreased in intratumoral vessels compared with peritumoral ones; this difference was independent of the tumour thickness. Loss of VAP-1 protein expression occurred in both endothelial and smooth muscle cell components. Unlike in other cancer types, the VAP-1 protein expression of intratumoral vessels did not correlate with the density of cytotoxic T-lymphocytes or dendritic cells. On the other hand, the 5-year survival of melanoma patients with low VAP-1 protein expression in intratumoral blood vessels (≤ 25%) was lower (26.3%) than in patients whose VAP-1 expression was higher (42.6%, P=0.0632). These results support the idea that the phenotype of intratumoral blood vessels is important in the progression of malignant melanoma.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalMelanoma Research
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 2004

Fingerprint

Microvessels
Blood Vessels
Melanoma
Skin
Proteins
Immunoelectron Microscopy
Cytotoxic T-Lymphocytes
Cellular Structures
Dendritic Cells
Smooth Muscle Myocytes
Neoplasms
Immunohistochemistry
Phenotype
Survival

Keywords

  • Intratumoral vessels
  • Melanoma
  • Survival
  • Vascular adhesion protein-1

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

Cite this

Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma. / Forster-Horváth, Csaba; Döme, B.; Paku, S.; Ladányi, A.; Somlai, B.; Jalkanen, Sirpa; Tímár, J.

In: Melanoma Research, Vol. 14, No. 2, 04.2004, p. 135-140.

Research output: Contribution to journalArticle

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