Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study

Peter Falkai, Bernhard Bogerts, Benno Greve, Ute Pfeiffer, Brigitte Machus, Babette Fölsch-Reetz, K. Majtényi, Imre Ovary

Research output: Contribution to journalArticle

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Abstract

The sylvian fissure is known to be one of the most asymmetric structures of the human brain. Sylvian fissure length was measured in post-mortem brains of 35 schizoprenic patients and 33 matched non psychiatric control subjects. The schizophrenics showed a significantly reduced length of the left sylvian fissure ( - 16%, p <0.0001) compared to the control subjects, while the right sylvian fissure length was unchanged. Sylvian fissure asymmetry (left/right ratio) was more reduced in male schizophrenics ( - 24%, p <0.001) than in female patients ( - 16%, p <0.03). This finding is consistent with several post-mortem and MRI studies showing left temporal lobe pathology in a significant proportion of patients and may indicate that schizophrenia is a disorder of early neurodevelopment causing impaired cerebral lateralization.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalSchizophrenia Research
Volume7
Issue number1
DOIs
Publication statusPublished - 1992

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Schizophrenia
Brain
Temporal Lobe
Psychiatry
Pathology

Keywords

  • (Schizophrenia)
  • Laterality
  • Post mortem study
  • Sylvian fissure

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Falkai, P., Bogerts, B., Greve, B., Pfeiffer, U., Machus, B., Fölsch-Reetz, B., ... Ovary, I. (1992). Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study. Schizophrenia Research, 7(1), 23-32. https://doi.org/10.1016/0920-9964(92)90070-L

Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study. / Falkai, Peter; Bogerts, Bernhard; Greve, Benno; Pfeiffer, Ute; Machus, Brigitte; Fölsch-Reetz, Babette; Majtényi, K.; Ovary, Imre.

In: Schizophrenia Research, Vol. 7, No. 1, 1992, p. 23-32.

Research output: Contribution to journalArticle

Falkai, P, Bogerts, B, Greve, B, Pfeiffer, U, Machus, B, Fölsch-Reetz, B, Majtényi, K & Ovary, I 1992, 'Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study', Schizophrenia Research, vol. 7, no. 1, pp. 23-32. https://doi.org/10.1016/0920-9964(92)90070-L
Falkai, Peter ; Bogerts, Bernhard ; Greve, Benno ; Pfeiffer, Ute ; Machus, Brigitte ; Fölsch-Reetz, Babette ; Majtényi, K. ; Ovary, Imre. / Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study. In: Schizophrenia Research. 1992 ; Vol. 7, No. 1. pp. 23-32.
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