Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study

Peter Falkai, Bernhard Bogerts, Benno Greve, Ute Pfeiffer, Brigitte Machus, Babette Fölsch-Reetz, Catherine Majtenyi, Imre Ovary

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The sylvian fissure is known to be one of the most asymmetric structures of the human brain. Sylvian fissure length was measured in post-mortem brains of 35 schizoprenic patients and 33 matched non psychiatric control subjects. The schizophrenics showed a significantly reduced length of the left sylvian fissure ( - 16%, p < 0.0001) compared to the control subjects, while the right sylvian fissure length was unchanged. Sylvian fissure asymmetry (left/right ratio) was more reduced in male schizophrenics ( - 24%, p < 0.001) than in female patients ( - 16%, p < 0.03). This finding is consistent with several post-mortem and MRI studies showing left temporal lobe pathology in a significant proportion of patients and may indicate that schizophrenia is a disorder of early neurodevelopment causing impaired cerebral lateralization.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalSchizophrenia Research
Issue number1
Publication statusPublished - Apr 1992



  • (Schizophrenia)
  • Laterality
  • Post mortem study
  • Sylvian fissure

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Falkai, P., Bogerts, B., Greve, B., Pfeiffer, U., Machus, B., Fölsch-Reetz, B., Majtenyi, C., & Ovary, I. (1992). Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study. Schizophrenia Research, 7(1), 23-32. https://doi.org/10.1016/0920-9964(92)90070-L