Loss of sensitivity to morphine induced by prolonged ACTH treatment

M. Fekete, Béla Kanyicska, Tibor Szentendrei, Ervin Stark

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of long term ACTH treatment on some actions of morphine were studied. The effect of ACTH administration was compared to that induced by acute dexamethasone injection. ACTH caused a delayed inhibition of the morphine induced increase in growth hormone secretion demonstrable 24 hr after the last hormone injection. The morphine induced increase of striatal DOPAC (3,4-dihydroxyphenylacetic acid) content was also inhibited by ACTH treatment, however, neither the analgesia, nor the hypermotility caused by morphine were affected. Dexamethasone did not alter significantly the responsiveness to morphine. It is concluded that the prolonged exposure to ACTH presumably causes a corticosterone-mediated loss of responsiveness of functionally restricted opiate sensitive mechanisms in the central nervous system.

Original languageEnglish
Pages (from-to)879-882
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume20
Issue number6
DOIs
Publication statusPublished - 1984

Fingerprint

Adrenocorticotropic Hormone
Morphine
Dexamethasone
Opiate Alkaloids
Therapeutics
Corpus Striatum
3,4-Dihydroxyphenylacetic Acid
Injections
Neurology
Corticosterone
Analgesia
Growth Hormone
Central Nervous System
Hormones

Keywords

  • ACTH
  • Analgesia
  • DOPAC
  • Glucocorticoids
  • Growth hormone
  • Morphine
  • Motility
  • Rats
  • Striatal

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Loss of sensitivity to morphine induced by prolonged ACTH treatment. / Fekete, M.; Kanyicska, Béla; Szentendrei, Tibor; Stark, Ervin.

In: Pharmacology, Biochemistry and Behavior, Vol. 20, No. 6, 1984, p. 879-882.

Research output: Contribution to journalArticle

Fekete, M. ; Kanyicska, Béla ; Szentendrei, Tibor ; Stark, Ervin. / Loss of sensitivity to morphine induced by prolonged ACTH treatment. In: Pharmacology, Biochemistry and Behavior. 1984 ; Vol. 20, No. 6. pp. 879-882.
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