Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin

Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Szilvassy, I. Nagy, J. Lonovics, M. Koltai

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33 Citations (Scopus)


A preceding right ventricular overdrive pacing (VOP) of 500 b.p.m. for 5 min, markedly reduced the severity of global myocardial ischaemia produced by a subsequent 5‐min VOP in conscious rabbits. This VOP‐induced preconditioning developed in parallel with an increase in cardiac cyclic guanosine 3′: 5′‐monophosphate (cyclic GMP) content. VOP‐induced preconditioning was abolished when the animals had been made tolerant to the vasodilator effect of nitroglycerin (NG). In the heart of the NG‐tolerant rabbits, neither VOP nor preconditioning increased cyclic GMP content. This suggests that changes by NG tolerance of cyclic GMP metabolism may account for the loss of VOP‐induced preconditioning. 1994 British Pharmacological Society

Original languageEnglish
Pages (from-to)999-1001
Number of pages3
JournalBritish journal of pharmacology
Issue number4
Publication statusPublished - Aug 1994


  • Ischaemic preconditioning
  • ST‐segment elevation
  • cyclic GMP
  • nitroglycerin tolerance
  • rabbit heart

ASJC Scopus subject areas

  • Pharmacology

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