Loss of monocyte membrane receptors in patients with SLE

M. Kavai, K. Lukacs, I. Sonkoly, I. J. Jókay, A. Berndt, G. Szegedi

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Abstract

Following an 80-min cold treatment of monocytes and their subsequent heating at 37°C a part of the Fc and C3 receptors is shed from the cells into the serum-free medium. However, while the reduced expression of cell membrane Fc receptors is regenerated at 37°C in 4-8 hr, that of the C3 receptors is not. Initially, the Fc receptor expression of monocytes for patients with SLE is greater than that of controls and after shedding it increases to the level of controls at 37°C in 4-8 hr. The expression and the regeneration of C3 receptors are equivalent to those of controls. The phagocytic ability of patient monocytes is lower than that of controls and the difference also remains after heat treatment.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalClinical and Experimental Immunology
Volume40
Issue number1
Publication statusPublished - Jul 11 1980

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Kavai, M., Lukacs, K., Sonkoly, I., Jókay, I. J., Berndt, A., & Szegedi, G. (1980). Loss of monocyte membrane receptors in patients with SLE. Clinical and Experimental Immunology, 40(1), 66-71.