Longitudinal Strain Reflects Ventriculoarterial Coupling Rather Than Mere Contractility in Rat Models of Hemodynamic Overload–Induced Heart Failure

Mihály Ruppert, Bálint Károly Lakatos, Szilveszter Braun, Márton Tokodi, Christian Karime, Attila Oláh, Alex Ali Sayour, István Hizoh, Bálint András Barta, Béla Merkely, Attila Kovács, T. Radovits

Research output: Contribution to journalArticle

Abstract

Background: Longitudinal strain (LS) is a sensitive marker of systolic function. Recent findings suggest that both myocardial contractility and loading conditions determine LS. The aim of this study was to investigate whether LS reflects the connection of cardiac contractility to afterload (termed ventriculoarterial coupling [VAC]) rather than mere contractility in rat models of hemodynamic overload–induced heart failure (HF). Methods: Pressure overload–induced HF was evoked by transverse aortic constriction (TAC; n = 14). Volume overload–induced HF was established by an aortocaval fistula (ACF; n = 12). Age-matched sham-operated animals served as controls for TAC (n = 14) and ACF (n = 12), respectively. Pressure-volume analysis was carried out to compute contractility (slope of end-systolic pressure-volume relationship [ESPVR]), afterload (arterial elastance [Ea]), and VAC (Ea/ESPVR). Preload was evaluated by meridional end-diastolic wall stress. Speckle-tracking echocardiography was performed to assess LS. Results: The TAC group presented with maintained ESPVR, increased Ea, and enhanced meridional end-diastolic wall stress. In contrast, the ACF group was characterized by reduced ESPVR, decreased Ea, and enhanced meridional end-diastolic wall stress. VAC increased in both HF groups. Furthermore, LS was also impaired in both HF models (−5.9 ± 0.6% vs −12.9 ± 0.5%, TAC vs Shamt [P < .001], and −11.7 ± 0.7% vs −13.5 ± 0.4%, ACF vs Shama[P = .048]). Statistical analysis revealed that strain parameters were determined predominantly by afterload in the TAC group and by contractility in the ACF group, while preload had a minor effect. In the entire study population, LS showed a correlation with VAC (R = 0.654, P < .001) but not with ESPVR (R = 0.058, P = .668). Conclusions: Under pathophysiologic conditions when both contractility and afterload become altered, LS reflects VAC rather than mere contractility.

Original languageEnglish
JournalJournal of the American Society of Echocardiography
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Contractility
  • Hemodynamic overload–induced heart failure
  • Longitudinal strain
  • Pressure-volume analysis
  • Ventriculoarterial coupling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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