Longevity nutrients resveratrol, wines and grapes

Istvan Lekli, Diptarka Ray, Dipak K. Das

Research output: Contribution to journalReview article

40 Citations (Scopus)


A mild-to-moderate wine drinking has been linked with reduced cardiovascular, cerebrovascular, and peripheral vascular risk as well as reduced risk due to cancer. The reduced risk of cardiovascular disease associated with wine drinking is popularly known as French Paradox. A large number of reports exist in the literature indicating that resveratrol present in wine is primarily responsible for the cardioprotection associated with wine. Recently, resveratrol was shown to extend life span in yeast through the activation of longevity gene SirT1, which is also responsible for the longevity mediated by calorie restriction. This review summarizes the reports available on the functional and molecular biological aspects of resveratrol, wine and grapes in potentiating the longevity genes.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalGenes and Nutrition
Issue number1
Publication statusPublished - Mar 2010


  • Longevity
  • Red wine
  • Resveratrol
  • SirT1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

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