Long-term survival after colorectal surgery associated with buffy-coat-poor and leucocyte-depleted blood transfusion: A follow-up study

Lone S. Jensen, E. Puhó, Lars Pedersen, Frank V. Mortensen, Henrik Toft Sørensen

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A Danish clinical trial showed that transfusion with leucocyte-depleted red blood cells reduces postoperative infectious complications compared with cells without buffy-coat. However, the effect on long-term outcome is unknown. We followed up the 142 cancer patients transfused with buffy-coat-poor red cells, the 118 transfused with leucocyte-depleted blood, and the 329 who were not transfused, until 2003. After 7 years' follow-up, survival for those with leucocyte-depleted blood transfusion (46 [41%]) was not significantly different from transfusion of blood without buffy-coat (59 [45%], p=0.51). Although survival is reduced by blood transfusion, it does not differ between the two transfusion regimens.

Original languageEnglish
Pages (from-to)681-682
Number of pages2
JournalThe Lancet
Volume365
Issue number9460
DOIs
Publication statusPublished - Feb 19 2005

Fingerprint

Colorectal Surgery
Blood Transfusion
Leukocytes
Blood Buffy Coat
Leukocyte Transfusion
Survival
Erythrocytes
Clinical Trials
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Long-term survival after colorectal surgery associated with buffy-coat-poor and leucocyte-depleted blood transfusion : A follow-up study. / Jensen, Lone S.; Puhó, E.; Pedersen, Lars; Mortensen, Frank V.; Sørensen, Henrik Toft.

In: The Lancet, Vol. 365, No. 9460, 19.02.2005, p. 681-682.

Research output: Contribution to journalArticle

Jensen, Lone S. ; Puhó, E. ; Pedersen, Lars ; Mortensen, Frank V. ; Sørensen, Henrik Toft. / Long-term survival after colorectal surgery associated with buffy-coat-poor and leucocyte-depleted blood transfusion : A follow-up study. In: The Lancet. 2005 ; Vol. 365, No. 9460. pp. 681-682.
@article{1a739e1be65f438f8ffb343608680a20,
title = "Long-term survival after colorectal surgery associated with buffy-coat-poor and leucocyte-depleted blood transfusion: A follow-up study",
abstract = "A Danish clinical trial showed that transfusion with leucocyte-depleted red blood cells reduces postoperative infectious complications compared with cells without buffy-coat. However, the effect on long-term outcome is unknown. We followed up the 142 cancer patients transfused with buffy-coat-poor red cells, the 118 transfused with leucocyte-depleted blood, and the 329 who were not transfused, until 2003. After 7 years' follow-up, survival for those with leucocyte-depleted blood transfusion (46 [41{\%}]) was not significantly different from transfusion of blood without buffy-coat (59 [45{\%}], p=0.51). Although survival is reduced by blood transfusion, it does not differ between the two transfusion regimens.",
author = "Jensen, {Lone S.} and E. Puh{\'o} and Lars Pedersen and Mortensen, {Frank V.} and S{\o}rensen, {Henrik Toft}",
year = "2005",
month = "2",
day = "19",
doi = "10.1016/S0140-6736(05)17949-5",
language = "English",
volume = "365",
pages = "681--682",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9460",

}

TY - JOUR

T1 - Long-term survival after colorectal surgery associated with buffy-coat-poor and leucocyte-depleted blood transfusion

T2 - A follow-up study

AU - Jensen, Lone S.

AU - Puhó, E.

AU - Pedersen, Lars

AU - Mortensen, Frank V.

AU - Sørensen, Henrik Toft

PY - 2005/2/19

Y1 - 2005/2/19

N2 - A Danish clinical trial showed that transfusion with leucocyte-depleted red blood cells reduces postoperative infectious complications compared with cells without buffy-coat. However, the effect on long-term outcome is unknown. We followed up the 142 cancer patients transfused with buffy-coat-poor red cells, the 118 transfused with leucocyte-depleted blood, and the 329 who were not transfused, until 2003. After 7 years' follow-up, survival for those with leucocyte-depleted blood transfusion (46 [41%]) was not significantly different from transfusion of blood without buffy-coat (59 [45%], p=0.51). Although survival is reduced by blood transfusion, it does not differ between the two transfusion regimens.

AB - A Danish clinical trial showed that transfusion with leucocyte-depleted red blood cells reduces postoperative infectious complications compared with cells without buffy-coat. However, the effect on long-term outcome is unknown. We followed up the 142 cancer patients transfused with buffy-coat-poor red cells, the 118 transfused with leucocyte-depleted blood, and the 329 who were not transfused, until 2003. After 7 years' follow-up, survival for those with leucocyte-depleted blood transfusion (46 [41%]) was not significantly different from transfusion of blood without buffy-coat (59 [45%], p=0.51). Although survival is reduced by blood transfusion, it does not differ between the two transfusion regimens.

UR - http://www.scopus.com/inward/record.url?scp=13844318809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844318809&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(05)17949-5

DO - 10.1016/S0140-6736(05)17949-5

M3 - Article

C2 - 15721474

AN - SCOPUS:13844318809

VL - 365

SP - 681

EP - 682

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9460

ER -