Long-term single-centre large volume experience with transseptal endocardial left ventricular lead implantation

László Gellér, Zoltán Salló, Levente Molnár, Tamás Tahin, Emin Evren Özcan, Valentina Kutyifa, István Osztheimer, Szabolcs Szilágyi, Nándor Szegedi, Pál Ábrahám, Astrid Apor, Klaudia Vivien Nagy, Annamária Kosztin, Dávid Becker, Szilvia Herczeg, Endre Zima, Béla Merkely

Research output: Contribution to journalArticle

1 Citation (Scopus)


AIMS: The aim of our study was to investigate the long-term efficacy and safety of transseptal endocardial left ventricular lead implantation (TELVLI). METHODS AND RESULTS: Transseptal endocardial left ventricular lead implantation was performed in 54 patients (44 men, median age 69, New York Heart Association III-IV stage) between 2007 and 2017 in a single centre. In 36 cases, the transseptal puncture (TP) was performed via the femoral vein, and in 18 cases, the TP and also the left ventricular (LV) lead placement were performed via the subclavian vein. An electrophysiological deflectable catheter was used to reach the LV wall through the dilated TP hole. The LV lead implantation was successful in all patients. A total of 54 patients were followed up for a median of 29 months [interquartile range (IQR) 8-40 months], the maximum follow-up time was 94 months. Significant improvement in the LV ejection fraction was observed at the 3-month visit, from the median of 27% (IQR 25-34%) to 33% (IQR 32-44%), P < 0.05. Early lead dislocation was observed in three cases (5%), reposition was performed using the original puncture site in all. The patients were maintained on anticoagulation therapy with a target international normalized ratio between 2.5 and 3.5. Four thromboembolic events were noticed during follow-up. A total of 27 patients died, with a median survival of 15 months (IQR 6-40). CONCLUSION: The TELVLI is an effective approach for cardiac resynchronization therapy (CRT) however it is associated with a substantial thromboembolic risk (7%).


  • Cardiac resynchronization therapy
  • Endocardial
  • Heart failure
  • Lead
  • Transseptal

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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