Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces

Richárd Fiáth, Katharina T. Hofer, Vivien Csikós, Domonkos Horváth, Tibor Nánási, Kinga Tóth, Frederick Pothof, Christian Böhler, Maria Asplund, Patrick Ruther, I. Ulbert

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6-12 macro- or microelectrodes), limited spatial resolution (0.5-1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices. The cylindrically-shaped depth probes made of polyimide (PI) were chronically implanted for 13 weeks into the brain of rats, while cortical or thalamic activity (local field potentials, single-unit and multi-unit activity) was recorded regularly to monitor the temporal change of several features of the electrophysiological performance. To examine the tissue reaction around the probe, neuron-selective and astroglia-selective immunostaining methods were applied. Stable single-unit and multi-unit activity were recorded for several weeks with the implanted depth probes and a weak or moderate tissue reaction was found around the probe track. Our data on biocompatibility presented here and in vivo experiments in non-human primates provide a strong indication that this type of neural probe can be applied in stereo-electroencephalography recordings of up to 2 weeks in humans targeting the localization of epileptic foci providing an increased spatial resolution and the ability to monitor local field potentials and neuronal spiking activity.

Original languageEnglish
JournalUnknown Journal
DOIs
Publication statusAccepted/In press - Feb 26 2018

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Biocompatibility
Polymers
Microelectrodes
Electroencephalography
Tissue
Polyimides
Neurons
Macros
Rats
Brain
Electrodes
Experiments

Keywords

  • depth probe
  • electrophysiological performance
  • histocompatibility
  • multielectrode recording
  • single-unit activity
  • stereo-electroencephalography

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces. / Fiáth, Richárd; Hofer, Katharina T.; Csikós, Vivien; Horváth, Domonkos; Nánási, Tibor; Tóth, Kinga; Pothof, Frederick; Böhler, Christian; Asplund, Maria; Ruther, Patrick; Ulbert, I.

In: Unknown Journal, 26.02.2018.

Research output: Contribution to journalArticle

Fiáth, Richárd ; Hofer, Katharina T. ; Csikós, Vivien ; Horváth, Domonkos ; Nánási, Tibor ; Tóth, Kinga ; Pothof, Frederick ; Böhler, Christian ; Asplund, Maria ; Ruther, Patrick ; Ulbert, I. / Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces. In: Unknown Journal. 2018.
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