Long-term prognostic value of coronary flow velocity reserve in patients with hypertrophic cardiomyopathy

9-year follow-up results from SZEGED study

Attila Nemes, Erika Balázs, Osama I I Soliman, Róbert Sepp, M. Csanády, T. Forster

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Reduction in coronary flow velocity reserve (CFR) is a recognized feature in hypertrophic cardiomyopathy (HCM). We sought to assess the long-term prognostic value of CFR by pulsed-wave Doppler transesophageal echocardiography (TEE) in HCM patients. The study comprised 20 patients with typical features of HCM. The patients were enrolled in 1999. All patients underwent a standard transthoracic echo-Doppler study to evaluate left ventricular function and a stress vasodilator TEE study to evaluate CFR. The success rate of follow-up was 18 out of 20 (90%). During a mean follow-up of 90 ± 24 months, four patients suffered cardiovascular death (2 sudden cardiac deaths and 2 strokes). The other seven patients underwent invasive procedures (coronary angiography, implantable cardioverter defibrillator implantation, percutaneous transluminal septal myocardial ablation) or showed cerebrovascular events. Using receiver operator characteristic analysis, CFR <2.35 was a significant predictor for cardiovascular event-free survival (sensitivity 91%, specificity 71%, area under the curve 74%, P = 0.05). Multivariable regression analysis showed that only CFR (hazard ratio (HR) 4.21, P <0.05) was an independent predictor of cardiovascular event-free survival. Despite the relatively small number of patients involved in the study, results could suggest that CFR should be considered as an independent predictor for future cardiovascular events in HCM patients. However, further studies with larger HCM patient populations are warranted.

Original languageEnglish
Pages (from-to)352-356
Number of pages5
JournalHeart and Vessels
Volume24
Issue number5
DOIs
Publication statusPublished - 2009

Fingerprint

Hypertrophic Cardiomyopathy
Transesophageal Echocardiography
Disease-Free Survival
Implantable Defibrillators
Doppler Echocardiography
Sudden Cardiac Death
Coronary Angiography
Vasodilator Agents
Left Ventricular Function
Area Under Curve
Stroke
Regression Analysis
Sensitivity and Specificity

Keywords

  • Cardiomyopathy
  • Coronary flow velocity reserve
  • Follow-up
  • Hypertrophic
  • Morbidity
  • Mortality
  • Prediction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-term prognostic value of coronary flow velocity reserve in patients with hypertrophic cardiomyopathy : 9-year follow-up results from SZEGED study. / Nemes, Attila; Balázs, Erika; Soliman, Osama I I; Sepp, Róbert; Csanády, M.; Forster, T.

In: Heart and Vessels, Vol. 24, No. 5, 2009, p. 352-356.

Research output: Contribution to journalArticle

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