A coronariaáramlási rezerv prognosztikus jelento′ sége a koronarográfia során a bal koszorúér leszálló szárában szignifikáns szukületet nem mutató betegekben: Eredmények a SZEGED Tanulmányból

Translated title of the contribution: Long-term prognostic value of coronary fl ow reserve in patients without signifi cant left anterior descending coronary artery stenosis: Results from the SZEGED Study

Erika Balázs, Kinga Szilvia Pintér, Ágnes Egyed, M. Csanády, T. Forster, Attila Nemes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Coronary flow reserve (CFR) measured by pulsed Doppler echocardiography is a useful hemodynamic index to evaluate coronary microcirculatory (dys)function in the left anterior descending coronary artery (LAD), in the absence of macrovascular lesions. Aims: The present study was designed to evaluate long-term prognostic value of CFR in patients without significant epicardial LAD stenosis. Methods: A total of 166 patients without significant LAD stenosis were enrolled in this prospective follow-up study. Coronary angiography demonstrated absence of significant LAD disease in all cases. All patients underwent transthoracic and stress transesophageal echocardiography (CFR measurement) and coronary angiography. Results: The success rate of follow-up was 124 out of 166 (75%). During a mean follow-up of 93±34 months 27 patients died, including 16 sudden cardiac deaths, 3 acute heart failures, 2 strokes, while 6 patients had pulmonary or gastrointestinal malignancies. Using ROC analysis, the best cut-off value for CFR was 2.13 to predict survival (sensitivity 67%, specificity 60%, area, under the curve 62%, p = 0.046). Patients with CFR <2.13 had significantly more events (32% vs. 13%, p

Original languageHungarian
Pages (from-to)338-343
Number of pages6
JournalOrvosi Hetilap
Volume151
Issue number9
DOIs
Publication statusPublished - Feb 1 2010

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Coronary Stenosis
Coronary Angiography
Pathologic Constriction
Doppler Pulsed Echocardiography
Stress Echocardiography
Sudden Cardiac Death
Transesophageal Echocardiography
ROC Curve
Area Under Curve
Coronary Vessels
Heart Failure
Hemodynamics
Stroke
Sensitivity and Specificity
Lung
Survival
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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A coronariaáramlási rezerv prognosztikus jelento′ sége a koronarográfia során a bal koszorúér leszálló szárában szignifikáns szukületet nem mutató betegekben : Eredmények a SZEGED Tanulmányból. / Balázs, Erika; Pintér, Kinga Szilvia; Egyed, Ágnes; Csanády, M.; Forster, T.; Nemes, Attila.

In: Orvosi Hetilap, Vol. 151, No. 9, 01.02.2010, p. 338-343.

Research output: Contribution to journalArticle

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abstract = "Coronary flow reserve (CFR) measured by pulsed Doppler echocardiography is a useful hemodynamic index to evaluate coronary microcirculatory (dys)function in the left anterior descending coronary artery (LAD), in the absence of macrovascular lesions. Aims: The present study was designed to evaluate long-term prognostic value of CFR in patients without significant epicardial LAD stenosis. Methods: A total of 166 patients without significant LAD stenosis were enrolled in this prospective follow-up study. Coronary angiography demonstrated absence of significant LAD disease in all cases. All patients underwent transthoracic and stress transesophageal echocardiography (CFR measurement) and coronary angiography. Results: The success rate of follow-up was 124 out of 166 (75{\%}). During a mean follow-up of 93±34 months 27 patients died, including 16 sudden cardiac deaths, 3 acute heart failures, 2 strokes, while 6 patients had pulmonary or gastrointestinal malignancies. Using ROC analysis, the best cut-off value for CFR was 2.13 to predict survival (sensitivity 67{\%}, specificity 60{\%}, area, under the curve 62{\%}, p = 0.046). Patients with CFR <2.13 had significantly more events (32{\%} vs. 13{\%}, p",
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AU - Pintér, Kinga Szilvia

AU - Egyed, Ágnes

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AU - Nemes, Attila

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