Long-term prognostic value of asymptomatic cardiac troponin T elevations in patients after major vascular surgery

M. Kertai, E. Boersma, J. Klein, H. van Urk, J. J. Bax, D. Poldermans

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Background. Cardiac troponin T (cTnT) is a sensitive and specific marker for myocardial injury, but elevations of cTnT without clinical evidence of ischemia and persistent or new electrocardiographic (ECG) abnormalities are common in patients undergoing major vascular surgery. We explored the long-term prognostic value of cTnT levels in these patients. Methods. A follow-up study was conducted between 1996-2000 in 393 patients who underwent successful aortic or infrainguinal vascular surgery and routine sampling of cTnT. Patients were followed until May 2003 (median of 4 years [25th-75th percentile, 2.8-5.3 years]). Total creatine kinase (CK), CK-MB, and cTnT were routinely screened in all patients, and included sampling after surgery and the mornings of postoperative days 2, 3 and 7. Electrocardiograms were also routinely evaluated for sign of ischemia. An elevated cTnT was defined as serum concentrations ≥0.1 ng/ml in any of these samples. All-cause mortality was evaluated during long-term follow-up. Results. Eighty patients (20%) had late death. The incidence of all-cause mortality (41% vs. 17%; p

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume28
Issue number1
DOIs
Publication statusPublished - Jul 2004

Fingerprint

Troponin T
Blood Vessels
Ischemia
MB Form Creatine Kinase
Mortality
Creatine Kinase
Electrocardiography
Incidence
Wounds and Injuries
Serum

Keywords

  • Follow-up studies
  • Major vascular surgery
  • Mortality
  • Myocardial ischemia
  • Troponin T

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Long-term prognostic value of asymptomatic cardiac troponin T elevations in patients after major vascular surgery. / Kertai, M.; Boersma, E.; Klein, J.; van Urk, H.; Bax, J. J.; Poldermans, D.

In: European Journal of Vascular and Endovascular Surgery, Vol. 28, No. 1, 07.2004, p. 59-66.

Research output: Contribution to journalArticle

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