Long-term post-treatment follow-up of onychomycosis treated with terbinafine: A multicentre trial

Ibolya Török, G. Simon, A. Dobozy, Beatrix Farkas, Csilla Mészáros, L. Nebenführer, Eva Szepes, Eva Tóth

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Abstract

Between 1991 and 1993, 32 cases of fingernail mycosis and 20 cases of toenail mycosis caused by dermatophytes were treated with terbinafine. For 8 weeks, 250 mg of terbinafine was given daily for fingernail infections, and for 12 weeks the same dose was given for toenail involvement; the short-term follow-up was 24 and 48 weeks respectively. A long-term follow-up was performed twice, initially at 24 and then at 48 months after the end of the treatment. For fingernail mycosis, the mycological cure rate was 100% at the end of month 24 and 91% at the end of month 48. Mycological cultures gave negative results in toenail infections in 90% after 24 months and in 86% after 48 months. After 24 months, 23 out of 26 patients (88%) with fingernail and 17 out of 20 patients (95%) with toenail mycosis were clinically cured, after 48 months, 20 out of 22 cases (91%) with fingernail and 10 out of 14 cases (71%) with toenail involvement showed a complete cure.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalMycoses
Volume41
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1998

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Keywords

  • Antimycotic chemotherapy
  • Follow-up study
  • Multicentre trial
  • Onychomycosis
  • Terbinafine

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Török, I., Simon, G., Dobozy, A., Farkas, B., Mészáros, C., Nebenführer, L., Szepes, E., & Tóth, E. (1998). Long-term post-treatment follow-up of onychomycosis treated with terbinafine: A multicentre trial. Mycoses, 41(1-2), 63-65. https://doi.org/10.1111/j.1439-0507.1998.tb00379.x