Long-term plasticity in mouse sensorimotor circuits after rhythmic whisker stimulation

Pierre Mégevand, Edgardo Troncoso, Charles Quairiaux, Dominique Muller, Christoph M. Michel, J. Kiss

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Mice actively explore their environment by rhythmically sweeping their whiskers. As a consequence, neuronal activity in somatosensory pathways is modulated by the frequency of whisker movement. The potential role of rhythmic neuronal activity for the integration and consolidation of sensory signals, however, remains unexplored. Here, we show that a brief period of rhythmic whisker stimulation in anesthetized mice resulted in a frequency-specific long-lasting increase in the amplitude of somatosensory-evoked potentials in the contralateral primary somatosensory (barrel) cortex. Mapping of evoked potentials and intracortical recordings revealed that, in addition to potentiation in layers IV and II/III of the barrel cortex, rhythmic whisker stimulation induced a decrease of somatosensory-evoked responses in the supragranular layers of the motor cortex. To assess whether rhythmic sensory input-based plasticity might arise in natural settings, we exposed mice to environmental enrichment. We found that it resulted in somatosensory-evoked responses of increased amplitude, highlighting the influence of previous sensory experience in shaping sensory responses. Importantly, environmental enrichment-induced plasticity occluded further potentiation by rhythmic stimulation, indicating that both phenomena share common mechanisms. Overall, our results suggest that natural, rhythmic patterns of whisker activity can modify the cerebral processing of sensory information, providing a possible mechanism for learning during sensory perception.

Original languageEnglish
Pages (from-to)5326-5335
Number of pages10
JournalJournal of Neuroscience
Volume29
Issue number16
DOIs
Publication statusPublished - Apr 22 2009

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Vibrissae
Somatosensory Cortex
Somatosensory Evoked Potentials
Motor Cortex
Automatic Data Processing
Evoked Potentials
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Long-term plasticity in mouse sensorimotor circuits after rhythmic whisker stimulation. / Mégevand, Pierre; Troncoso, Edgardo; Quairiaux, Charles; Muller, Dominique; Michel, Christoph M.; Kiss, J.

In: Journal of Neuroscience, Vol. 29, No. 16, 22.04.2009, p. 5326-5335.

Research output: Contribution to journalArticle

Mégevand, Pierre ; Troncoso, Edgardo ; Quairiaux, Charles ; Muller, Dominique ; Michel, Christoph M. ; Kiss, J. / Long-term plasticity in mouse sensorimotor circuits after rhythmic whisker stimulation. In: Journal of Neuroscience. 2009 ; Vol. 29, No. 16. pp. 5326-5335.
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