In the present study we tested the preconditioning effect of repeated beta adrenergic stress induced by Isoproterenol in chronically instrumented, conscious rabbits. We have found that at least 5 intravenous administrations of Isoproterenol, repeated at 10 min intervals, were necessary to induce a long-term cardiac adaptation manifested by a significant reduction of the harmful ischaemic changes due to cardiac stress 24 and 48 hours after preconditioning. These results suggest that a well-defined threshold level of the preconditioning stress is needed to trigger induction of metabolic changes leading to development of delayed and long-term cardiac adaptation.
|Number of pages||2|
|Journal||Acta physiologica Hungarica|
|Publication status||Published - Dec 1 1996|
- Long-term ischaemic preconditioning
- Repeated β-adrenergic stress
ASJC Scopus subject areas
- Physiology (medical)