Long-term ischaemic preconditioning of the heart induced by repeated β-adrenergic stress

I. Kovanecz, J. Gy Papp, L. Szekeres

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present study we tested the preconditioning effect of repeated beta adrenergic stress induced by Isoproterenol in chronically instrumented, conscious rabbits. We have found that at least 5 intravenous administrations of Isoproterenol, repeated at 10 min intervals, were necessary to induce a long-term cardiac adaptation manifested by a significant reduction of the harmful ischaemic changes due to cardiac stress 24 and 48 hours after preconditioning. These results suggest that a well-defined threshold level of the preconditioning stress is needed to trigger induction of metabolic changes leading to development of delayed and long-term cardiac adaptation.

Original languageEnglish
Pages (from-to)297-298
Number of pages2
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - Dec 1 1996

Keywords

  • Heart
  • Long-term ischaemic preconditioning
  • Repeated β-adrenergic stress

ASJC Scopus subject areas

  • Physiology (medical)

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