Long-term gravitational load via head-up tilting induces increase of innervation density in rat saphenous vessel

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Abstract

In a previous study we found that head-up tilting for two weeks significantly enhanced the sympathetic component of smooth muscle membrane potential in the saphenous vein (SV) but not in the saphenous artery (SA) and the brachial vessels of rats (Am. J. Physiol. 256: HI 18591,1989). The aim of the present study was to quantitate and compare the density of nerve fibers (DN) as well as their synaptic vésicule population (DV) in saphenous vessels from tilted rats (T) and from those maintained in horizontal position (C). DN (No/100 urn cross sectional area of vascular wall) of SV and SA did not differ significantly in the C group (1.91±0.74 and 2.05±0.23, respectively). Tilting resulted in a significantly larger increase in DN of SA (3.42±036 SE) than in that of SV (2.65±0.79). DV (No of vesicules/10 fiber sections) was substantially higher in SA than in SV of C, but its percent increase due to tilting was more than twice as large in SV (174.2%) than in SA (8.05±2.11 vs. 22.07 5.52, and 35.06±11.31 vs. 64.87±3.26, respectively). These findings support the hypothesis that long-term gravitational load may result in functional and morphological redistribution of vascular sympathetic innervation:.

Original languageEnglish
JournalFASEB Journal
Volume10
Issue number3
Publication statusPublished - 1996

Fingerprint

saphenous vein
Saphenous Vein
innervation
arteries
Rats
Head
nerve fibers
Arteries
Nerve Fibers
Fibers
rats
blood vessels
Blood Vessels
Brachial Artery
Muscle
membrane potential
Membrane Potentials
smooth muscle
Smooth Muscle
Membranes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

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abstract = "In a previous study we found that head-up tilting for two weeks significantly enhanced the sympathetic component of smooth muscle membrane potential in the saphenous vein (SV) but not in the saphenous artery (SA) and the brachial vessels of rats (Am. J. Physiol. 256: HI 18591,1989). The aim of the present study was to quantitate and compare the density of nerve fibers (DN) as well as their synaptic v{\'e}sicule population (DV) in saphenous vessels from tilted rats (T) and from those maintained in horizontal position (C). DN (No/100 urn cross sectional area of vascular wall) of SV and SA did not differ significantly in the C group (1.91±0.74 and 2.05±0.23, respectively). Tilting resulted in a significantly larger increase in DN of SA (3.42±036 SE) than in that of SV (2.65±0.79). DV (No of vesicules/10 fiber sections) was substantially higher in SA than in SV of C, but its percent increase due to tilting was more than twice as large in SV (174.2{\%}) than in SA (8.05±2.11 vs. 22.07 5.52, and 35.06±11.31 vs. 64.87±3.26, respectively). These findings support the hypothesis that long-term gravitational load may result in functional and morphological redistribution of vascular sympathetic innervation:.",
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