Long-term follow-up of patients with persistent/recurrent, isolated haematuria: A Hungarian multicentre study

S. Túri, M. Visy, A. Vissy, V. Jászai, Zs Czirbesz, I. Haszon, Zs Szelid, I. Ferkis

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A retrospective multicentre study of 341 children with persistent/recurrent, isolated haematuria is described. The haematuria was isolated for at least 6 months at the beginning of observation. The duration of follow-up was 2-5 years in 201, 5-10 years in 119, 10-15 years in 19, and over 15 years in 2 cases. Of these patients 47.8% became symptom-free. In 18.4% the haematuria remained isolated; in 13.8% it was combined with proteinuria over 250 mg/day more than 2 years later. The occurrence of associated proteinuria increased progressively with time. It was 8.6% between the 3rd and 5th years, and 37.0% after the 5th year. Renal biopsy was performed because of the symptoms of glomerular disease in 47 cases at an average time of 12 months following the appearance of proteinuria. Proteinuria appeared after a 2-5, 5-10, 10-15 and more than 15 years follow-up period in 16, 23, 6, and 2 patients respectively; 14 of them had Alport's nephropathy. The percentage of more serious azotaemia was 1.7 (creatinine clearance: 10-50 ml/min per 1.73 m2) and 0.3 (creatinine clearance: <10 ml/min per 1.73 m2). Mortality was 0.58%. Most of the patients who developed severe azotaemia had persistent microscopic haematuria at the beginning. The prevalence of hypertension was only 1.2%. The time of its appearance was above 5 years in 2 and below 5 years in 2 cases. All these patients had chronic glomerulonephritis. The haematuria was associated with hypercalciuria in 19.9%. In 14.3% of the overall group of patients urolithiasis developed 2-15 years after onset. All of these had hypercalciuria. Our findings suggest that symptoms of isolated haematuria may last for a longterm period and need systematic control. When proteinuria and/or hypertension is associated with haematuria a worse prognosis can be expected.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalPediatric Nephrology
Volume3
Issue number3
DOIs
Publication statusPublished - Sep 1989

Fingerprint

Hematuria
Multicenter Studies
Proteinuria
Azotemia
Hypercalciuria
Creatinine
Hypertension
Urolithiasis
Glomerulonephritis
Retrospective Studies
Observation
Kidney
Biopsy
Mortality

Keywords

  • Follow-up
  • Haematuria, persistent/recurrent, isolated

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Long-term follow-up of patients with persistent/recurrent, isolated haematuria : A Hungarian multicentre study. / Túri, S.; Visy, M.; Vissy, A.; Jászai, V.; Czirbesz, Zs; Haszon, I.; Szelid, Zs; Ferkis, I.

In: Pediatric Nephrology, Vol. 3, No. 3, 09.1989, p. 235-239.

Research output: Contribution to journalArticle

Túri, S. ; Visy, M. ; Vissy, A. ; Jászai, V. ; Czirbesz, Zs ; Haszon, I. ; Szelid, Zs ; Ferkis, I. / Long-term follow-up of patients with persistent/recurrent, isolated haematuria : A Hungarian multicentre study. In: Pediatric Nephrology. 1989 ; Vol. 3, No. 3. pp. 235-239.
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N2 - A retrospective multicentre study of 341 children with persistent/recurrent, isolated haematuria is described. The haematuria was isolated for at least 6 months at the beginning of observation. The duration of follow-up was 2-5 years in 201, 5-10 years in 119, 10-15 years in 19, and over 15 years in 2 cases. Of these patients 47.8% became symptom-free. In 18.4% the haematuria remained isolated; in 13.8% it was combined with proteinuria over 250 mg/day more than 2 years later. The occurrence of associated proteinuria increased progressively with time. It was 8.6% between the 3rd and 5th years, and 37.0% after the 5th year. Renal biopsy was performed because of the symptoms of glomerular disease in 47 cases at an average time of 12 months following the appearance of proteinuria. Proteinuria appeared after a 2-5, 5-10, 10-15 and more than 15 years follow-up period in 16, 23, 6, and 2 patients respectively; 14 of them had Alport's nephropathy. The percentage of more serious azotaemia was 1.7 (creatinine clearance: 10-50 ml/min per 1.73 m2) and 0.3 (creatinine clearance: <10 ml/min per 1.73 m2). Mortality was 0.58%. Most of the patients who developed severe azotaemia had persistent microscopic haematuria at the beginning. The prevalence of hypertension was only 1.2%. The time of its appearance was above 5 years in 2 and below 5 years in 2 cases. All these patients had chronic glomerulonephritis. The haematuria was associated with hypercalciuria in 19.9%. In 14.3% of the overall group of patients urolithiasis developed 2-15 years after onset. All of these had hypercalciuria. Our findings suggest that symptoms of isolated haematuria may last for a longterm period and need systematic control. When proteinuria and/or hypertension is associated with haematuria a worse prognosis can be expected.

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