Dermatofi brosarcoma protuberans multidiszciplináris kezelésével szerzett hosszú távú eredmények 26 betegnél

Translated title of the contribution: Long-term experiences with multidisciplinary therapy of twenty-six patients with dermatofi brosarcoma protuberans and review of the literature

Zoltán Mátrai, Gabriella Liszkay, Vanda Plotár, Zsolt Orosz, Judit Székely, E. Hitre, Alexandra Bartal, Zoltán Langmár, Katalin Bocs, Ferenc Rényi Vámos, Ákos Sávolt, L. Tóth

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dermatofibrosarcoma protuberans is a low or moderate grade malignant, uncommon soft tissue tumor. The tumor is characterized by slow, but locally aggressive growth, low metastatic potential and high recurrence rate. Initial treatment is the radical surgical excision, using traditional wide excision or Mohs surgery. In case of positive surgical margin or local recurrence, radio-chemotherapy and recently imatinib mesylate is used as adjuvant therapy. Aims: Twenty-six patients treated multidisciplinary for dermatofibrosarcoma protuberans were followed up. Methods and Results: Mean age of the patients was 44.7 years; mean follow-up time was 60.57 months. In fifteen cases (57.7%) R0 resection was performed, while eleven patients (42,3%) received only R1 resection. An average of 1.87 resections was necessary in order to achieve R0 resection. Six patients (23%) received adjuvant radiotherapy and two patients (7.6%) adjuvant chemotherapy following the removal of the primary tumor. Sixteen patients had no local recurrence. Ongoing treatments were needed in the case of ten patients (38.4%) who developed local recurrence. One patient has deceased due to distant metastases. Using statistical methods we examined the effects indicated as prognostic factors in the literature on local recurrence, precisely, the effect of age above 50 years and surgical radicalism. Conclusions: Dermatofibrosarcoma protuberans can be successfully treated with multidisciplinary therapy. A larger number of cases and randomized multicenter investigations are needed in order to reach more accurate conclusion.

Original languageHungarian
Pages (from-to)1894-1902
Number of pages9
JournalOrvosi Hetilap
Volume150
Issue number41
DOIs
Publication statusPublished - Oct 1 2009

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Dermatofibrosarcoma
Recurrence
Therapeutics
Mohs Surgery
Neoplasms
Adjuvant Radiotherapy
Adjuvant Chemotherapy
Radio
Neoplasm Metastasis
Drug Therapy
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dermatofi brosarcoma protuberans multidiszciplináris kezelésével szerzett hosszú távú eredmények 26 betegnél. / Mátrai, Zoltán; Liszkay, Gabriella; Plotár, Vanda; Orosz, Zsolt; Székely, Judit; Hitre, E.; Bartal, Alexandra; Langmár, Zoltán; Bocs, Katalin; Rényi Vámos, Ferenc; Sávolt, Ákos; Tóth, L.

In: Orvosi Hetilap, Vol. 150, No. 41, 01.10.2009, p. 1894-1902.

Research output: Contribution to journalArticle

Mátrai, Z, Liszkay, G, Plotár, V, Orosz, Z, Székely, J, Hitre, E, Bartal, A, Langmár, Z, Bocs, K, Rényi Vámos, F, Sávolt, Á & Tóth, L 2009, 'Dermatofi brosarcoma protuberans multidiszciplináris kezelésével szerzett hosszú távú eredmények 26 betegnél', Orvosi Hetilap, vol. 150, no. 41, pp. 1894-1902. https://doi.org/10.1556/OH.2009.28702
Mátrai, Zoltán ; Liszkay, Gabriella ; Plotár, Vanda ; Orosz, Zsolt ; Székely, Judit ; Hitre, E. ; Bartal, Alexandra ; Langmár, Zoltán ; Bocs, Katalin ; Rényi Vámos, Ferenc ; Sávolt, Ákos ; Tóth, L. / Dermatofi brosarcoma protuberans multidiszciplináris kezelésével szerzett hosszú távú eredmények 26 betegnél. In: Orvosi Hetilap. 2009 ; Vol. 150, No. 41. pp. 1894-1902.
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abstract = "Dermatofibrosarcoma protuberans is a low or moderate grade malignant, uncommon soft tissue tumor. The tumor is characterized by slow, but locally aggressive growth, low metastatic potential and high recurrence rate. Initial treatment is the radical surgical excision, using traditional wide excision or Mohs surgery. In case of positive surgical margin or local recurrence, radio-chemotherapy and recently imatinib mesylate is used as adjuvant therapy. Aims: Twenty-six patients treated multidisciplinary for dermatofibrosarcoma protuberans were followed up. Methods and Results: Mean age of the patients was 44.7 years; mean follow-up time was 60.57 months. In fifteen cases (57.7{\%}) R0 resection was performed, while eleven patients (42,3{\%}) received only R1 resection. An average of 1.87 resections was necessary in order to achieve R0 resection. Six patients (23{\%}) received adjuvant radiotherapy and two patients (7.6{\%}) adjuvant chemotherapy following the removal of the primary tumor. Sixteen patients had no local recurrence. Ongoing treatments were needed in the case of ten patients (38.4{\%}) who developed local recurrence. One patient has deceased due to distant metastases. Using statistical methods we examined the effects indicated as prognostic factors in the literature on local recurrence, precisely, the effect of age above 50 years and surgical radicalism. Conclusions: Dermatofibrosarcoma protuberans can be successfully treated with multidisciplinary therapy. A larger number of cases and randomized multicenter investigations are needed in order to reach more accurate conclusion.",
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AU - Liszkay, Gabriella

AU - Plotár, Vanda

AU - Orosz, Zsolt

AU - Székely, Judit

AU - Hitre, E.

AU - Bartal, Alexandra

AU - Langmár, Zoltán

AU - Bocs, Katalin

AU - Rényi Vámos, Ferenc

AU - Sávolt, Ákos

AU - Tóth, L.

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N2 - Dermatofibrosarcoma protuberans is a low or moderate grade malignant, uncommon soft tissue tumor. The tumor is characterized by slow, but locally aggressive growth, low metastatic potential and high recurrence rate. Initial treatment is the radical surgical excision, using traditional wide excision or Mohs surgery. In case of positive surgical margin or local recurrence, radio-chemotherapy and recently imatinib mesylate is used as adjuvant therapy. Aims: Twenty-six patients treated multidisciplinary for dermatofibrosarcoma protuberans were followed up. Methods and Results: Mean age of the patients was 44.7 years; mean follow-up time was 60.57 months. In fifteen cases (57.7%) R0 resection was performed, while eleven patients (42,3%) received only R1 resection. An average of 1.87 resections was necessary in order to achieve R0 resection. Six patients (23%) received adjuvant radiotherapy and two patients (7.6%) adjuvant chemotherapy following the removal of the primary tumor. Sixteen patients had no local recurrence. Ongoing treatments were needed in the case of ten patients (38.4%) who developed local recurrence. One patient has deceased due to distant metastases. Using statistical methods we examined the effects indicated as prognostic factors in the literature on local recurrence, precisely, the effect of age above 50 years and surgical radicalism. Conclusions: Dermatofibrosarcoma protuberans can be successfully treated with multidisciplinary therapy. A larger number of cases and randomized multicenter investigations are needed in order to reach more accurate conclusion.

AB - Dermatofibrosarcoma protuberans is a low or moderate grade malignant, uncommon soft tissue tumor. The tumor is characterized by slow, but locally aggressive growth, low metastatic potential and high recurrence rate. Initial treatment is the radical surgical excision, using traditional wide excision or Mohs surgery. In case of positive surgical margin or local recurrence, radio-chemotherapy and recently imatinib mesylate is used as adjuvant therapy. Aims: Twenty-six patients treated multidisciplinary for dermatofibrosarcoma protuberans were followed up. Methods and Results: Mean age of the patients was 44.7 years; mean follow-up time was 60.57 months. In fifteen cases (57.7%) R0 resection was performed, while eleven patients (42,3%) received only R1 resection. An average of 1.87 resections was necessary in order to achieve R0 resection. Six patients (23%) received adjuvant radiotherapy and two patients (7.6%) adjuvant chemotherapy following the removal of the primary tumor. Sixteen patients had no local recurrence. Ongoing treatments were needed in the case of ten patients (38.4%) who developed local recurrence. One patient has deceased due to distant metastases. Using statistical methods we examined the effects indicated as prognostic factors in the literature on local recurrence, precisely, the effect of age above 50 years and surgical radicalism. Conclusions: Dermatofibrosarcoma protuberans can be successfully treated with multidisciplinary therapy. A larger number of cases and randomized multicenter investigations are needed in order to reach more accurate conclusion.

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