Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete's heart

Alexandra Polyák, Péter Kui, Nikolett Morvay, I. Leprán, Gergely Ágoston, A. Varga, N. Nagy, I. Baczkó, Andrá Farkas, J. Papp, Andrá Varró, Attila S. Farkas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sudden cardiac death in athletes is rare and most often unexpectable. For a better understanding of cardiac remodeling, this study presents the effects of chronic vigorous exercise on cardiac structure and electrophysiology in new rabbit and dog athlete's heart models. Rabbits and dogs were randomized into sedentary ('Sed'), exercised (subjected to 16 weeks chronic treadmill exercise ('Ex') groups, and a testosterone-treated ('Dop') group in dogs. Echocardiography and electrocardiogram were performed. Proarrhythmic sensitivity and autonomic responses were tested in conscious dogs. 'Ex' animals exhibited left ventricular enlargement with bradycardia (mean RR in 'Ex' vs. 'Sed' rabbits: 335 ± 15 vs. 288 ±19 ms, p ≤ 0.05, and in 'Dop' vs. 'Ex' vs. 'Sed' dogs: 718 ± 6 vs. 638 ± 38 vs. 599 ± 49 ms) accompanied by an increase of heart rate variability in both species (e.g. SD RR in 'Ex' vs. 'Sed' rabbits: 3.4 ± 0.9 vs. 1.4 ± 0.1 ms, p ≤ 0.05, and in 'Dop' vs. 'Ex' vs. 'Sed' dogs: 156 ± 59 vs. 163 ± 44 vs. 111 ± 49 ms) indicating an increased vagal tone. A lower response to parasympatholytic agent atropine and more pronounced QTc interval lengthening after dofetilide challenge were found in 'Ex' and 'Dop' dogs compared to the 'Sed' group. No morphological and functional changes were found after chronic steroid treatment in dogs. The structural-functional findings share more similarities with human athlete's heart. Slight repolarization sensitivity in the exercised dogs may indicate an increased risk of arrhythmias in athletes under different circumstances. These animal models might be useful for the further investigations of the cardiovascular effects of competitive training.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalReviews in cardiovascular medicine
Volume19
Issue number4
DOIs
Publication statusPublished - Dec 30 2018

Fingerprint

Athletes
Animal Models
Dogs
Rabbits
Cardiac Electrophysiology
Exercise
Parasympatholytics
Sudden Cardiac Death
Bradycardia
Atropine
Echocardiography
Testosterone
Cardiac Arrhythmias
Electrocardiography
Heart Rate
Steroids

Keywords

  • cardiac function
  • cardiac structure
  • echocardiography
  • electrophysiology
  • Endurance exercise
  • remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete's heart. / Polyák, Alexandra; Kui, Péter; Morvay, Nikolett; Leprán, I.; Ágoston, Gergely; Varga, A.; Nagy, N.; Baczkó, I.; Farkas, Andrá; Papp, J.; Varró, Andrá; Farkas, Attila S.

In: Reviews in cardiovascular medicine, Vol. 19, No. 4, 30.12.2018, p. 135-142.

Research output: Contribution to journalArticle

Polyák, Alexandra ; Kui, Péter ; Morvay, Nikolett ; Leprán, I. ; Ágoston, Gergely ; Varga, A. ; Nagy, N. ; Baczkó, I. ; Farkas, Andrá ; Papp, J. ; Varró, Andrá ; Farkas, Attila S. / Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete's heart. In: Reviews in cardiovascular medicine. 2018 ; Vol. 19, No. 4. pp. 135-142.
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