Long-term drug survival and predictor analysis of the whole psoriatic patient population on biological therapy in Hungary

Lilla Pogácsás, András Borsi, Péter Takács, Éva Remenyik, Lajos Kemény, Sarolta Kárpáti, Péter Holló, Norbert Wikonkál, Rolland Gyulai, Zsuzsanna Károlyi, Pál Rakonczai, Tamás Balázs, Andrea Szegedi

Research output: Contribution to journalArticle

12 Citations (Scopus)


Persistence is an important component of therapeutic success, which depends on a variety of factors. Persistence measured under optimal conditions during clinical trials does not necessarily coincide with persistence observed in the real-world settings. The aim of the present study was to compare persistence rate of TNF-alpha inhibitors and interleukin 12/23 inhibitor in all psoriasis patients in Hungary, as well as to analyze the predictors of persistence. Data collected from 1263 patients over a period of 46 months were subjected to a retrospective analysis. Drug survival rate has been calculated according to Kaplan–Meier analysis and Cox regression was used to study the predictors. The overall persistence rate for the four biologicals exceeded 60% after 3 years. The persistence rate of ustekinumab at 3 years was 67.83%, which was superior compared to that of the TNF-alpha inhibitors, where the mean persistence rate was shown to be 50.76% (p <.05). Male patients showed significantly higher persistence than females (HR =.76, p <.05 CI: 0.63, 0.92). Age, therapy-naïve status and use of concomitant MTX did not have significant effect on drug survival. Persistence rate of ustekinumab was significantly higher than that of TNF-alpha inhibitors, and among predictors, only male gender influenced persistence significantly.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalJournal of Dermatological Treatment
Issue number7
Publication statusPublished - Oct 3 2017


  • Biological therapy
  • comparison
  • hazard ratios
  • persistence
  • predictors
  • psoriasis

ASJC Scopus subject areas

  • Dermatology

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