Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients

Róbert Szegedi, G. Széplaki, L. Varga, Z. Prohászka, Zoltán Széplaki, I. Karádi, G. Füst, H. Farkas

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Hereditary angioedema (HAE) is characterized by episodic edematous attacks due to the deficiency of the C1-inhibitor (C1-INH). Recently, we have described that the long-term use of danazol affects lipid metabolism, resulting in decreased high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL) cholesterol levels, which might lead to accelerated, early atherosclerosis. Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients. Methods: The prevalence of vascular disease, as well as carotid intima-media thickness (IMT) - an objective marker of atherosclerosis - was determined in 32 HAE patients undergoing danazol prophylaxis, and compared to 25 HAE patients without danazol treatment, as well as to 20 healthy controls. Distinct atherosclerosis risk profiles were determined in addition. Results: HAE patients with danazol prophylaxis had higher body mass index (p = 0.0055 and 0.0020), creatinine (p = 0.0001 and 0.0130), alanine aminotransferase (p = 0.0298 and 0.0457), LDL (p = 0.0060 and

Original languageEnglish
Pages (from-to)184-191
Number of pages8
JournalAtherosclerosis
Volume198
Issue number1
DOIs
Publication statusPublished - May 2008

Fingerprint

Hereditary Angioedemas
Danazol
Carotid Intima-Media Thickness
Atherosclerosis
HDL Lipoproteins
Alanine Transaminase
Vascular Diseases
LDL Lipoproteins
Lipid Metabolism
LDL Cholesterol
Creatinine
Body Mass Index
Therapeutics

Keywords

  • Adverse effects
  • Atherosclerosis
  • Carotid arteries
  • Danazol
  • HDL
  • Hereditary angioedema (HAE)
  • Intima-media thickness (IMT)
  • LDL
  • Lipids
  • Total cholesterol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{76761d1654344f22918265498df23d21,
title = "Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients",
abstract = "Background: Hereditary angioedema (HAE) is characterized by episodic edematous attacks due to the deficiency of the C1-inhibitor (C1-INH). Recently, we have described that the long-term use of danazol affects lipid metabolism, resulting in decreased high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL) cholesterol levels, which might lead to accelerated, early atherosclerosis. Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients. Methods: The prevalence of vascular disease, as well as carotid intima-media thickness (IMT) - an objective marker of atherosclerosis - was determined in 32 HAE patients undergoing danazol prophylaxis, and compared to 25 HAE patients without danazol treatment, as well as to 20 healthy controls. Distinct atherosclerosis risk profiles were determined in addition. Results: HAE patients with danazol prophylaxis had higher body mass index (p = 0.0055 and 0.0020), creatinine (p = 0.0001 and 0.0130), alanine aminotransferase (p = 0.0298 and 0.0457), LDL (p = 0.0060 and",
keywords = "Adverse effects, Atherosclerosis, Carotid arteries, Danazol, HDL, Hereditary angioedema (HAE), Intima-media thickness (IMT), LDL, Lipids, Total cholesterol",
author = "R{\'o}bert Szegedi and G. Sz{\'e}plaki and L. Varga and Z. Proh{\'a}szka and Zolt{\'a}n Sz{\'e}plaki and I. Kar{\'a}di and G. F{\"u}st and H. Farkas",
year = "2008",
month = "5",
doi = "10.1016/j.atherosclerosis.2007.09.025",
language = "English",
volume = "198",
pages = "184--191",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients

AU - Szegedi, Róbert

AU - Széplaki, G.

AU - Varga, L.

AU - Prohászka, Z.

AU - Széplaki, Zoltán

AU - Karádi, I.

AU - Füst, G.

AU - Farkas, H.

PY - 2008/5

Y1 - 2008/5

N2 - Background: Hereditary angioedema (HAE) is characterized by episodic edematous attacks due to the deficiency of the C1-inhibitor (C1-INH). Recently, we have described that the long-term use of danazol affects lipid metabolism, resulting in decreased high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL) cholesterol levels, which might lead to accelerated, early atherosclerosis. Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients. Methods: The prevalence of vascular disease, as well as carotid intima-media thickness (IMT) - an objective marker of atherosclerosis - was determined in 32 HAE patients undergoing danazol prophylaxis, and compared to 25 HAE patients without danazol treatment, as well as to 20 healthy controls. Distinct atherosclerosis risk profiles were determined in addition. Results: HAE patients with danazol prophylaxis had higher body mass index (p = 0.0055 and 0.0020), creatinine (p = 0.0001 and 0.0130), alanine aminotransferase (p = 0.0298 and 0.0457), LDL (p = 0.0060 and

AB - Background: Hereditary angioedema (HAE) is characterized by episodic edematous attacks due to the deficiency of the C1-inhibitor (C1-INH). Recently, we have described that the long-term use of danazol affects lipid metabolism, resulting in decreased high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL) cholesterol levels, which might lead to accelerated, early atherosclerosis. Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients. Methods: The prevalence of vascular disease, as well as carotid intima-media thickness (IMT) - an objective marker of atherosclerosis - was determined in 32 HAE patients undergoing danazol prophylaxis, and compared to 25 HAE patients without danazol treatment, as well as to 20 healthy controls. Distinct atherosclerosis risk profiles were determined in addition. Results: HAE patients with danazol prophylaxis had higher body mass index (p = 0.0055 and 0.0020), creatinine (p = 0.0001 and 0.0130), alanine aminotransferase (p = 0.0298 and 0.0457), LDL (p = 0.0060 and

KW - Adverse effects

KW - Atherosclerosis

KW - Carotid arteries

KW - Danazol

KW - HDL

KW - Hereditary angioedema (HAE)

KW - Intima-media thickness (IMT)

KW - LDL

KW - Lipids

KW - Total cholesterol

UR - http://www.scopus.com/inward/record.url?scp=40949141935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40949141935&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2007.09.025

DO - 10.1016/j.atherosclerosis.2007.09.025

M3 - Article

VL - 198

SP - 184

EP - 191

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -