Long-term changes of activity of cortical neurons after status epilepticus induced at early developmental stages in rats

J. Doczi, K. Bernášková, H. Kubová, L. Détari, I. Világi, R. Druga, P. Mareš

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Abstract

Spontaneous activity of cortical neurons was studied under urethane anesthesia in adult rats 3 months after convulsive status epilepticus induced by lithium-pilocarpine administration at the age of 12 (SE12 group) or 25 (SE25 group) days. Whereas random firing neurons dominated in control animals (61 out of 98 cells), SE25 animals exhibited a significant increase in the incidence of bursting cells (38 out of 59 units). Similar change in SE12 animals did not reach the level of statistical significance. Status epilepticus at an early developmental stage may result in a long-lasting change in functions of surviving cortical neurons.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Volume352
Issue number2
DOIs
Publication statusPublished - Dec 11 2003

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Keywords

  • Cerebral cortex
  • Consequences of status epilepticus
  • Development
  • Rat
  • Unit activity

ASJC Scopus subject areas

  • Neuroscience(all)

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