Long-term arrhythmia variability after monomorphic ventricular tachycardia in patients with an implantable cardioverter defibrillator

Marcell Clemens, Edina Nagy-Baló, Csaba Herczku, Csaba Kun, I. Édes, Zoltán CsanÁdi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Arrhythmia burden in patients receiving an implantable cardioverter defibrillator (ICD) after monomorphic ventricular tachycardia (mVT) is higher than in patients with other indications. We investigated the long-term arrhythmia profile in this subset of patients. Methods: Fifty-two patients with an ICD implanted after mVT were followed up for at least 3 months. The cycle lengths (CLs) of the tachycardias recovered from the device memory were compared with the CL of the index arrhythmia. Morphological analysis of the intracardiac electrograms was performed and the response to antitachycardia pacing (ATP) was also assessed. Results: A total of 833 mVT episodes with intracardiac electrograms occurred during the follow-up (3-58 months; mean: 30.3 months) in 41 of the 52 patients analyzed. mVTs with different CLs as compared with the index mVT were found in 26 (50.0%), and at least two different mVT morphologies were observed in 28 (53.8%) patients. Multiple mVT morphologies were predictive of lower ATP efficacy (95.6%, 85.0%, and 70.3% in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001) and a higher shock burden (4.2%, 19.3%, and 24.7% in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001). Conclusion: A high mVT burden was demonstrated with marked variability of the arrhythmias as concerns both CL and morphology in patients with an ICD implanted for mVT. Multiple mVT morphologies during the follow-up were predictive of lower ATP efficacy and a higher shock burden.

Original languageEnglish
Pages (from-to)1185-1191
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Implantable Defibrillators
Ventricular Tachycardia
Cardiac Arrhythmias
Cardiac Electrophysiologic Techniques
Shock
Tachycardia

Keywords

  • cycle length
  • implantable cardioverter defibrillator
  • index arrhythmia
  • intracardiac electrogram
  • ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-term arrhythmia variability after monomorphic ventricular tachycardia in patients with an implantable cardioverter defibrillator. / Clemens, Marcell; Nagy-Baló, Edina; Herczku, Csaba; Kun, Csaba; Édes, I.; CsanÁdi, Zoltán.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 34, No. 10, 10.2011, p. 1185-1191.

Research output: Contribution to journalArticle

Clemens, Marcell ; Nagy-Baló, Edina ; Herczku, Csaba ; Kun, Csaba ; Édes, I. ; CsanÁdi, Zoltán. / Long-term arrhythmia variability after monomorphic ventricular tachycardia in patients with an implantable cardioverter defibrillator. In: PACE - Pacing and Clinical Electrophysiology. 2011 ; Vol. 34, No. 10. pp. 1185-1191.
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abstract = "Background: Arrhythmia burden in patients receiving an implantable cardioverter defibrillator (ICD) after monomorphic ventricular tachycardia (mVT) is higher than in patients with other indications. We investigated the long-term arrhythmia profile in this subset of patients. Methods: Fifty-two patients with an ICD implanted after mVT were followed up for at least 3 months. The cycle lengths (CLs) of the tachycardias recovered from the device memory were compared with the CL of the index arrhythmia. Morphological analysis of the intracardiac electrograms was performed and the response to antitachycardia pacing (ATP) was also assessed. Results: A total of 833 mVT episodes with intracardiac electrograms occurred during the follow-up (3-58 months; mean: 30.3 months) in 41 of the 52 patients analyzed. mVTs with different CLs as compared with the index mVT were found in 26 (50.0{\%}), and at least two different mVT morphologies were observed in 28 (53.8{\%}) patients. Multiple mVT morphologies were predictive of lower ATP efficacy (95.6{\%}, 85.0{\%}, and 70.3{\%} in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001) and a higher shock burden (4.2{\%}, 19.3{\%}, and 24.7{\%} in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001). Conclusion: A high mVT burden was demonstrated with marked variability of the arrhythmias as concerns both CL and morphology in patients with an ICD implanted for mVT. Multiple mVT morphologies during the follow-up were predictive of lower ATP efficacy and a higher shock burden.",
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AU - Clemens, Marcell

AU - Nagy-Baló, Edina

AU - Herczku, Csaba

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AU - Édes, I.

AU - CsanÁdi, Zoltán

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N2 - Background: Arrhythmia burden in patients receiving an implantable cardioverter defibrillator (ICD) after monomorphic ventricular tachycardia (mVT) is higher than in patients with other indications. We investigated the long-term arrhythmia profile in this subset of patients. Methods: Fifty-two patients with an ICD implanted after mVT were followed up for at least 3 months. The cycle lengths (CLs) of the tachycardias recovered from the device memory were compared with the CL of the index arrhythmia. Morphological analysis of the intracardiac electrograms was performed and the response to antitachycardia pacing (ATP) was also assessed. Results: A total of 833 mVT episodes with intracardiac electrograms occurred during the follow-up (3-58 months; mean: 30.3 months) in 41 of the 52 patients analyzed. mVTs with different CLs as compared with the index mVT were found in 26 (50.0%), and at least two different mVT morphologies were observed in 28 (53.8%) patients. Multiple mVT morphologies were predictive of lower ATP efficacy (95.6%, 85.0%, and 70.3% in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001) and a higher shock burden (4.2%, 19.3%, and 24.7% in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001). Conclusion: A high mVT burden was demonstrated with marked variability of the arrhythmias as concerns both CL and morphology in patients with an ICD implanted for mVT. Multiple mVT morphologies during the follow-up were predictive of lower ATP efficacy and a higher shock burden.

AB - Background: Arrhythmia burden in patients receiving an implantable cardioverter defibrillator (ICD) after monomorphic ventricular tachycardia (mVT) is higher than in patients with other indications. We investigated the long-term arrhythmia profile in this subset of patients. Methods: Fifty-two patients with an ICD implanted after mVT were followed up for at least 3 months. The cycle lengths (CLs) of the tachycardias recovered from the device memory were compared with the CL of the index arrhythmia. Morphological analysis of the intracardiac electrograms was performed and the response to antitachycardia pacing (ATP) was also assessed. Results: A total of 833 mVT episodes with intracardiac electrograms occurred during the follow-up (3-58 months; mean: 30.3 months) in 41 of the 52 patients analyzed. mVTs with different CLs as compared with the index mVT were found in 26 (50.0%), and at least two different mVT morphologies were observed in 28 (53.8%) patients. Multiple mVT morphologies were predictive of lower ATP efficacy (95.6%, 85.0%, and 70.3% in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001) and a higher shock burden (4.2%, 19.3%, and 24.7% in the patients with 1, 2, and 3 or more mVT morphologies, respectively; P <0.0001). Conclusion: A high mVT burden was demonstrated with marked variability of the arrhythmias as concerns both CL and morphology in patients with an ICD implanted for mVT. Multiple mVT morphologies during the follow-up were predictive of lower ATP efficacy and a higher shock burden.

KW - cycle length

KW - implantable cardioverter defibrillator

KW - index arrhythmia

KW - intracardiac electrogram

KW - ventricular tachycardia

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