Long term acth induced diminished responsiveness of prolactin secretion to morphine

B. Kanyicska, E. Stark, Gy Horváth, Á Simonyi, M. Fekete

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effect of morphine on plasma prolactin level and on dopamine turnover in the median eminence was studied using adult male rats chronically treated with ACTH. It was found that the ACTH pretreatment caused a decrease in the effect of morphine on prolactin secretion and prevented the inhibitory effect of morphine on dopamine turnover measured in the median eminence. The prolonged ACTH administration did not influence the prolactin content of the pituitaries and the in vitro dopamine sensitivity of lactotroph cells. Acute dexamethasone injection did not change the morphine-caused prolactin release. These results suggest that chronic ACTH treatment (possibly via corticosterone hyperproduction) elicites an opiate-tolerance like state of tuberoinfundibular dopaminergic neurons.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalLife Sciences
Volume33
Issue number1
DOIs
Publication statusPublished - Jul 4 1983

Fingerprint

Prolactin
Adrenocorticotropic Hormone
Morphine
Dopamine
Median Eminence
Opiate Alkaloids
Lactotrophs
Dopaminergic Neurons
Corticosterone
Dexamethasone
Neurons
Rats
Plasmas
Injections
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Long term acth induced diminished responsiveness of prolactin secretion to morphine. / Kanyicska, B.; Stark, E.; Horváth, Gy; Simonyi, Á; Fekete, M.

In: Life Sciences, Vol. 33, No. 1, 04.07.1983, p. 55-63.

Research output: Contribution to journalArticle

Kanyicska, B. ; Stark, E. ; Horváth, Gy ; Simonyi, Á ; Fekete, M. / Long term acth induced diminished responsiveness of prolactin secretion to morphine. In: Life Sciences. 1983 ; Vol. 33, No. 1. pp. 55-63.
@article{3ec4a4e190654dafa4e88d7b701480ad,
title = "Long term acth induced diminished responsiveness of prolactin secretion to morphine",
abstract = "The effect of morphine on plasma prolactin level and on dopamine turnover in the median eminence was studied using adult male rats chronically treated with ACTH. It was found that the ACTH pretreatment caused a decrease in the effect of morphine on prolactin secretion and prevented the inhibitory effect of morphine on dopamine turnover measured in the median eminence. The prolonged ACTH administration did not influence the prolactin content of the pituitaries and the in vitro dopamine sensitivity of lactotroph cells. Acute dexamethasone injection did not change the morphine-caused prolactin release. These results suggest that chronic ACTH treatment (possibly via corticosterone hyperproduction) elicites an opiate-tolerance like state of tuberoinfundibular dopaminergic neurons.",
author = "B. Kanyicska and E. Stark and Gy Horv{\'a}th and {\'A} Simonyi and M. Fekete",
year = "1983",
month = "7",
day = "4",
doi = "10.1016/0024-3205(83)90711-7",
language = "English",
volume = "33",
pages = "55--63",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Long term acth induced diminished responsiveness of prolactin secretion to morphine

AU - Kanyicska, B.

AU - Stark, E.

AU - Horváth, Gy

AU - Simonyi, Á

AU - Fekete, M.

PY - 1983/7/4

Y1 - 1983/7/4

N2 - The effect of morphine on plasma prolactin level and on dopamine turnover in the median eminence was studied using adult male rats chronically treated with ACTH. It was found that the ACTH pretreatment caused a decrease in the effect of morphine on prolactin secretion and prevented the inhibitory effect of morphine on dopamine turnover measured in the median eminence. The prolonged ACTH administration did not influence the prolactin content of the pituitaries and the in vitro dopamine sensitivity of lactotroph cells. Acute dexamethasone injection did not change the morphine-caused prolactin release. These results suggest that chronic ACTH treatment (possibly via corticosterone hyperproduction) elicites an opiate-tolerance like state of tuberoinfundibular dopaminergic neurons.

AB - The effect of morphine on plasma prolactin level and on dopamine turnover in the median eminence was studied using adult male rats chronically treated with ACTH. It was found that the ACTH pretreatment caused a decrease in the effect of morphine on prolactin secretion and prevented the inhibitory effect of morphine on dopamine turnover measured in the median eminence. The prolonged ACTH administration did not influence the prolactin content of the pituitaries and the in vitro dopamine sensitivity of lactotroph cells. Acute dexamethasone injection did not change the morphine-caused prolactin release. These results suggest that chronic ACTH treatment (possibly via corticosterone hyperproduction) elicites an opiate-tolerance like state of tuberoinfundibular dopaminergic neurons.

UR - http://www.scopus.com/inward/record.url?scp=0020581536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020581536&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(83)90711-7

DO - 10.1016/0024-3205(83)90711-7

M3 - Article

VL - 33

SP - 55

EP - 63

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 1

ER -