Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions

L. Kalmár, Veronika Acs, D. Silhavy, Peter Tompa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalJournal of Molecular Biology
Volume424
Issue number3-4
DOIs
Publication statusPublished - Dec 7 2012

Fingerprint

Nonsense Mediated mRNA Decay
Intrinsically Disordered Proteins
Nonsense Codon
RNA Stability
Computational Biology
Diptera
Communication
Messenger RNA
Proteins

Keywords

  • fly-casting
  • long-range interaction
  • nonsense-mediated decay
  • protein disorder

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions. / Kalmár, L.; Acs, Veronika; Silhavy, D.; Tompa, Peter.

In: Journal of Molecular Biology, Vol. 424, No. 3-4, 07.12.2012, p. 125-131.

Research output: Contribution to journalArticle

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