Long-lasting treatment with adenosine receptor antagonists: Effects on hypoxic tolerance and vascular responsiveness

Á Cseppento, A. Ujfalusi, K. Antal, J. Szegi, J. Zs Szabó, P. Kovács, A. J. Szentmiklósi

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Abstract

In electrically driven myocardial preparations obtained from chronically methylxanthine-[aminophylline (APH) and 8-phenyltheophylline (8-PT)] or solvent(DMSO)-treated guinea pigs no differences were found in alteration of mechanical activity under hypoxia and reoxygenation. The vasoconstrictor effects observed after in vitro exposure of pulmonary arterial preparations (excised from either methylxanthine- or solvent-treated guinea pigs) to both noradrenaline and PGF were also similar. In methylxanthine-treated vascular tissues, however, nitroglycerin and NO exerted more pronounced vasorelaxant effect than in specimens prepared from solvent-treated guinea pigs.

Original languageEnglish
Pages (from-to)275-276
Number of pages2
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - Dec 1 1996

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Keywords

  • Hypoxia
  • Methylxanthines
  • Myocardium
  • NO
  • Noradrenaline
  • Pulmonary artery

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Cseppento, Á., Ujfalusi, A., Antal, K., Szegi, J., Szabó, J. Z., Kovács, P., & Szentmiklósi, A. J. (1996). Long-lasting treatment with adenosine receptor antagonists: Effects on hypoxic tolerance and vascular responsiveness. Acta physiologica Hungarica, 84(3), 275-276.