Long-lasting potentiation of synaptic transmission requires postnaptic modifications in the neocortex

Attila Baranyi, Magdolna B. Szente

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The mechanisms of associative long-lasting potentiation (LLP) of excitatory postsynaptic potentials (EPSPs) were studied in the motor cortex of anethetized cats. Mono- and oligosynaptic EPSPs were evoked by stimulations of thalamic VL nucleus, pyramidal tract, callosal and somatosensory system and paired with orthodromic, antidromic or current-induced action potentials. EPSP-spike stimulus pairs with 0.1-0.2 Hz frequency and 0-200 ms interstimulus intervals induced increases in the amplitudes and durations of EPSPs for 40-60 min or longer after 20-50 pairings. The LLP was prevented when postsynaptic firing was blocked by intracellular current injection or by juxtasomatic application of ψ-aminobutyric acid. LLP was also prevented when the level of intracellular free celcium was lowered by the intracellular injection of the calcium chelator EGTA or when neuronal transport was blocked by the intracellular injection of colchicine. Neither EGTA nor colchicine blocked postsynaptic firing. Thus, these finding slow that LLP in the neocortex is a postsynaptic phenomenon which requires conjuctive pre- and postsynaptic activity, adequate levels of intracellular free calcium, and functional intracellular transport.

Original languageEnglish
Pages (from-to)378-384
Number of pages7
JournalBrain research
Volume423
Issue number1-2
DOIs
Publication statusPublished - Oct 13 1987

Keywords

  • Colchicine
  • Conditioning
  • EGTA
  • Intracellular recording
  • Motor cortex
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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