Long-lasting persistence of elevated sister-chromatid exchange frequencies induced by perinatal benzo(a)pyrene treatment in rat bone-marrow cells

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Abstract

In this work the possibility that a mutagenic factor acting in utero or in the perinatal period might lead to elevated mutagenic rates in bone-marrow cells after a considerable period of time was examined. An aromatic hydrocarbon, benzo(a)pyrene was used as the test substance. Benzo(a)pyrene treatments resulted in significantly higher sister-chromatid exchange (SCE)-frequencies in both fetal and neonatal groups in both sexes, even four months after exposure. In a second experiment we examined whether mutagenic exposure suffered in utero could make the individual more susceptible to mutagenic effects in adulthood. Preliminary results indicate that such a possibility could exist.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalExperientia
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 1 1995

Keywords

  • Benzo(a)pyrene
  • bone-marrow
  • sensitisation
  • sister-chromatid exchange

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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