Abstract
No extensive information exists in literature concerning the late or residual effects of stress on motility of small bowel and colon. Moreover, the duration and magnitude of the intestinal motor response to stress are still ignored. Therefore, the aim of our work was to determine, in rat, the effect of long-duration stress induced by restraint on the motility of small bowel and colon. Observations were made during physical restraint and 60 h later. Bipolar electrodes were implanted on the gastrointestinal serosa from the pylorus to the sigmoid colon in male Wistar rats. Electromyographic (EMG) recordings were made during fasting state, and a control EMG recording session was performed during 12 hr, followed by a 12-hr recording during restraint stress. After a 60-hr resting period, another EMG recording session was performed during 3 hr. During stress in the pylorus and small bowel, the recurrence of migrating myoelectrical complexes (MMCs) was immediately interrupted and replaced by a continuous and irregular activity. The motility index (number of spike bursts/10 min) was augmented rapidly on the jejunum and ileum, but it increased only gradually on the pylorus. Only on the transverse colon were the number of spike bursts/hour and their relative duration increased after 7 hr of physical restraint. In contrast, the sigmoid colon displayed a gradual decrease in the relative duration of contractile activity during the first 6-7 hr of stress. At 60 hr after stress in the pylorus and small bowel, a normal control motor activity was restored (MMC, motility index) on the jejunum and on the ileum, but the motility index on the pylorus was decreased. Throughout the colon, a faster motor activity as well as an increase in the number of spike bursts/hour was observed. In conclusion, a 12hr physical restraint stress induced instant drastic changes in small bowel motility, but a normal motility pattern was rapidly restored after the end of the stress period. However, on the colon, the motor changes are moderate at the beginning of the restraint period, then gradually increased with time, and were still largely persistent three days after the cessation of physical restraint.
| Original language | English |
|---|---|
| Pages (from-to) | 495-500 |
| Number of pages | 6 |
| Journal | Digestive Diseases and Sciences |
| Volume | 35 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1990 |
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Keywords
- electromyography
- intestinal motility
- rats
- stress
ASJC Scopus subject areas
- Gastroenterology
Cite this
Long-duration stress - Immediate and late effects on small and large bowel motility in rat. / Wittmann, T.; Crenner, F.; Angel, F.; Hanusz, L.; Ringwald, C.; Grenier, J. F.
In: Digestive Diseases and Sciences, Vol. 35, No. 4, 04.1990, p. 495-500.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-duration stress - Immediate and late effects on small and large bowel motility in rat
AU - Wittmann, T.
AU - Crenner, F.
AU - Angel, F.
AU - Hanusz, L.
AU - Ringwald, C.
AU - Grenier, J. F.
PY - 1990/4
Y1 - 1990/4
N2 - No extensive information exists in literature concerning the late or residual effects of stress on motility of small bowel and colon. Moreover, the duration and magnitude of the intestinal motor response to stress are still ignored. Therefore, the aim of our work was to determine, in rat, the effect of long-duration stress induced by restraint on the motility of small bowel and colon. Observations were made during physical restraint and 60 h later. Bipolar electrodes were implanted on the gastrointestinal serosa from the pylorus to the sigmoid colon in male Wistar rats. Electromyographic (EMG) recordings were made during fasting state, and a control EMG recording session was performed during 12 hr, followed by a 12-hr recording during restraint stress. After a 60-hr resting period, another EMG recording session was performed during 3 hr. During stress in the pylorus and small bowel, the recurrence of migrating myoelectrical complexes (MMCs) was immediately interrupted and replaced by a continuous and irregular activity. The motility index (number of spike bursts/10 min) was augmented rapidly on the jejunum and ileum, but it increased only gradually on the pylorus. Only on the transverse colon were the number of spike bursts/hour and their relative duration increased after 7 hr of physical restraint. In contrast, the sigmoid colon displayed a gradual decrease in the relative duration of contractile activity during the first 6-7 hr of stress. At 60 hr after stress in the pylorus and small bowel, a normal control motor activity was restored (MMC, motility index) on the jejunum and on the ileum, but the motility index on the pylorus was decreased. Throughout the colon, a faster motor activity as well as an increase in the number of spike bursts/hour was observed. In conclusion, a 12hr physical restraint stress induced instant drastic changes in small bowel motility, but a normal motility pattern was rapidly restored after the end of the stress period. However, on the colon, the motor changes are moderate at the beginning of the restraint period, then gradually increased with time, and were still largely persistent three days after the cessation of physical restraint.
AB - No extensive information exists in literature concerning the late or residual effects of stress on motility of small bowel and colon. Moreover, the duration and magnitude of the intestinal motor response to stress are still ignored. Therefore, the aim of our work was to determine, in rat, the effect of long-duration stress induced by restraint on the motility of small bowel and colon. Observations were made during physical restraint and 60 h later. Bipolar electrodes were implanted on the gastrointestinal serosa from the pylorus to the sigmoid colon in male Wistar rats. Electromyographic (EMG) recordings were made during fasting state, and a control EMG recording session was performed during 12 hr, followed by a 12-hr recording during restraint stress. After a 60-hr resting period, another EMG recording session was performed during 3 hr. During stress in the pylorus and small bowel, the recurrence of migrating myoelectrical complexes (MMCs) was immediately interrupted and replaced by a continuous and irregular activity. The motility index (number of spike bursts/10 min) was augmented rapidly on the jejunum and ileum, but it increased only gradually on the pylorus. Only on the transverse colon were the number of spike bursts/hour and their relative duration increased after 7 hr of physical restraint. In contrast, the sigmoid colon displayed a gradual decrease in the relative duration of contractile activity during the first 6-7 hr of stress. At 60 hr after stress in the pylorus and small bowel, a normal control motor activity was restored (MMC, motility index) on the jejunum and on the ileum, but the motility index on the pylorus was decreased. Throughout the colon, a faster motor activity as well as an increase in the number of spike bursts/hour was observed. In conclusion, a 12hr physical restraint stress induced instant drastic changes in small bowel motility, but a normal motility pattern was rapidly restored after the end of the stress period. However, on the colon, the motor changes are moderate at the beginning of the restraint period, then gradually increased with time, and were still largely persistent three days after the cessation of physical restraint.
KW - electromyography
KW - intestinal motility
KW - rats
KW - stress
UR - http://www.scopus.com/inward/record.url?scp=0025219707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025219707&partnerID=8YFLogxK
U2 - 10.1007/BF01536925
DO - 10.1007/BF01536925
M3 - Article
C2 - 2318096
AN - SCOPUS:0025219707
VL - 35
SP - 495
EP - 500
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 4
ER -