Long-duration stress - Immediate and late effects on small and large bowel motility in rat

T. Wittmann, F. Crenner, F. Angel, L. Hanusz, C. Ringwald, J. F. Grenier

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

No extensive information exists in literature concerning the late or residual effects of stress on motility of small bowel and colon. Moreover, the duration and magnitude of the intestinal motor response to stress are still ignored. Therefore, the aim of our work was to determine, in rat, the effect of long-duration stress induced by restraint on the motility of small bowel and colon. Observations were made during physical restraint and 60 h later. Bipolar electrodes were implanted on the gastrointestinal serosa from the pylorus to the sigmoid colon in male Wistar rats. Electromyographic (EMG) recordings were made during fasting state, and a control EMG recording session was performed during 12 hr, followed by a 12-hr recording during restraint stress. After a 60-hr resting period, another EMG recording session was performed during 3 hr. During stress in the pylorus and small bowel, the recurrence of migrating myoelectrical complexes (MMCs) was immediately interrupted and replaced by a continuous and irregular activity. The motility index (number of spike bursts/10 min) was augmented rapidly on the jejunum and ileum, but it increased only gradually on the pylorus. Only on the transverse colon were the number of spike bursts/hour and their relative duration increased after 7 hr of physical restraint. In contrast, the sigmoid colon displayed a gradual decrease in the relative duration of contractile activity during the first 6-7 hr of stress. At 60 hr after stress in the pylorus and small bowel, a normal control motor activity was restored (MMC, motility index) on the jejunum and on the ileum, but the motility index on the pylorus was decreased. Throughout the colon, a faster motor activity as well as an increase in the number of spike bursts/hour was observed. In conclusion, a 12hr physical restraint stress induced instant drastic changes in small bowel motility, but a normal motility pattern was rapidly restored after the end of the stress period. However, on the colon, the motor changes are moderate at the beginning of the restraint period, then gradually increased with time, and were still largely persistent three days after the cessation of physical restraint.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalDigestive Diseases and Sciences
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 1990

Fingerprint

Physical Restraint
Pylorus
Colon
Sigmoid Colon
Jejunum
Ileum
Motor Activity
Serous Membrane
Transverse Colon
Implanted Electrodes
Wistar Rats
Fasting
Recurrence

Keywords

  • electromyography
  • intestinal motility
  • rats
  • stress

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Long-duration stress - Immediate and late effects on small and large bowel motility in rat. / Wittmann, T.; Crenner, F.; Angel, F.; Hanusz, L.; Ringwald, C.; Grenier, J. F.

In: Digestive Diseases and Sciences, Vol. 35, No. 4, 04.1990, p. 495-500.

Research output: Contribution to journalArticle

Wittmann, T. ; Crenner, F. ; Angel, F. ; Hanusz, L. ; Ringwald, C. ; Grenier, J. F. / Long-duration stress - Immediate and late effects on small and large bowel motility in rat. In: Digestive Diseases and Sciences. 1990 ; Vol. 35, No. 4. pp. 495-500.
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