Koraszülöttek rövid és hosszú távú szövocombining double acute accentdményei. A hormonális háttér és a genetikai polimorfizmusok jelentocombining double acute accentsége

Translated title of the contribution: Long and short-term complications of the preterm neonate. Endocrine risk factors and the implication of genetic polymorphisms

Kovács Lajos, Treszl András, B. Vásárhelyi

Research output: Contribution to journalArticle

Abstract

The perinatal mortality and morbidity of the preterm neonates are severalfold higher than those of term healthy neonates. Furthermore, in addiction to the perinatal complications the risk of adulthood disorders is also higher in those adults who were born with low birth weight. Our research group performed two major studies in preterm infants. We have demonstrated that the susceptibility to chronic adult disorders is present even in young adults born preterm. Altered endocrine milieu i.e. increased adrenal activity may contribute to this phenomenon. In another study we extensively investigated those genetic polymorphisms that determinate inflammatory reaction and vasoregulation. We identified several genetic polymorphisms that determinate the risk of perinatal complications. Interestingly, we found some genetic polymorphisms that have a beneficial effect on the short-term complications of the newborn, but may adversely affect the risk of cardiovascular disorders in the adulthood. The aim of our further studies is to investigate the immune functions in preterm neonates and analyze association of altered immune functions with perinatal complications and therapies.

Original languageHungarian
Pages (from-to)109-114
Number of pages6
JournalOrvoskepzes
Volume82
Issue number3
Publication statusPublished - 2007

Fingerprint

Genetic Polymorphisms
Newborn Infant
Perinatal Mortality
Low Birth Weight Infant
Premature Infants
Young Adult
Morbidity
Research
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Korasz{\"u}l{\"o}ttek r{\"o}vid {\'e}s hossz{\'u} t{\'a}v{\'u} sz{\"o}vocombining double acute accentdm{\'e}nyei. A hormon{\'a}lis h{\'a}tt{\'e}r {\'e}s a genetikai polimorfizmusok jelentocombining double acute accents{\'e}ge",
abstract = "The perinatal mortality and morbidity of the preterm neonates are severalfold higher than those of term healthy neonates. Furthermore, in addiction to the perinatal complications the risk of adulthood disorders is also higher in those adults who were born with low birth weight. Our research group performed two major studies in preterm infants. We have demonstrated that the susceptibility to chronic adult disorders is present even in young adults born preterm. Altered endocrine milieu i.e. increased adrenal activity may contribute to this phenomenon. In another study we extensively investigated those genetic polymorphisms that determinate inflammatory reaction and vasoregulation. We identified several genetic polymorphisms that determinate the risk of perinatal complications. Interestingly, we found some genetic polymorphisms that have a beneficial effect on the short-term complications of the newborn, but may adversely affect the risk of cardiovascular disorders in the adulthood. The aim of our further studies is to investigate the immune functions in preterm neonates and analyze association of altered immune functions with perinatal complications and therapies.",
keywords = "Adrenal hormone, Complication, Genetic polymorphism, Preterm neonate",
author = "Kov{\'a}cs Lajos and Treszl Andr{\'a}s and B. V{\'a}s{\'a}rhelyi",
year = "2007",
language = "Hungarian",
volume = "82",
pages = "109--114",
journal = "Orvoskepzes",
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publisher = "Semmelweis Kiado",
number = "3",

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TY - JOUR

T1 - Koraszülöttek rövid és hosszú távú szövocombining double acute accentdményei. A hormonális háttér és a genetikai polimorfizmusok jelentocombining double acute accentsége

AU - Lajos, Kovács

AU - András, Treszl

AU - Vásárhelyi, B.

PY - 2007

Y1 - 2007

N2 - The perinatal mortality and morbidity of the preterm neonates are severalfold higher than those of term healthy neonates. Furthermore, in addiction to the perinatal complications the risk of adulthood disorders is also higher in those adults who were born with low birth weight. Our research group performed two major studies in preterm infants. We have demonstrated that the susceptibility to chronic adult disorders is present even in young adults born preterm. Altered endocrine milieu i.e. increased adrenal activity may contribute to this phenomenon. In another study we extensively investigated those genetic polymorphisms that determinate inflammatory reaction and vasoregulation. We identified several genetic polymorphisms that determinate the risk of perinatal complications. Interestingly, we found some genetic polymorphisms that have a beneficial effect on the short-term complications of the newborn, but may adversely affect the risk of cardiovascular disorders in the adulthood. The aim of our further studies is to investigate the immune functions in preterm neonates and analyze association of altered immune functions with perinatal complications and therapies.

AB - The perinatal mortality and morbidity of the preterm neonates are severalfold higher than those of term healthy neonates. Furthermore, in addiction to the perinatal complications the risk of adulthood disorders is also higher in those adults who were born with low birth weight. Our research group performed two major studies in preterm infants. We have demonstrated that the susceptibility to chronic adult disorders is present even in young adults born preterm. Altered endocrine milieu i.e. increased adrenal activity may contribute to this phenomenon. In another study we extensively investigated those genetic polymorphisms that determinate inflammatory reaction and vasoregulation. We identified several genetic polymorphisms that determinate the risk of perinatal complications. Interestingly, we found some genetic polymorphisms that have a beneficial effect on the short-term complications of the newborn, but may adversely affect the risk of cardiovascular disorders in the adulthood. The aim of our further studies is to investigate the immune functions in preterm neonates and analyze association of altered immune functions with perinatal complications and therapies.

KW - Adrenal hormone

KW - Complication

KW - Genetic polymorphism

KW - Preterm neonate

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