The perinatal mortality and morbidity of the preterm neonates are severalfold higher than those of term healthy neonates. Furthermore, in addiction to the perinatal complications the risk of adulthood disorders is also higher in those adults who were born with low birth weight. Our research group performed two major studies in preterm infants. We have demonstrated that the susceptibility to chronic adult disorders is present even in young adults born preterm. Altered endocrine milieu i.e. increased adrenal activity may contribute to this phenomenon. In another study we extensively investigated those genetic polymorphisms that determinate inflammatory reaction and vasoregulation. We identified several genetic polymorphisms that determinate the risk of perinatal complications. Interestingly, we found some genetic polymorphisms that have a beneficial effect on the short-term complications of the newborn, but may adversely affect the risk of cardiovascular disorders in the adulthood. The aim of our further studies is to investigate the immune functions in preterm neonates and analyze association of altered immune functions with perinatal complications and therapies.
|Number of pages||6|
|Publication status||Published - Dec 1 2007|
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