Location-dependent differences between somatic and dendritic IPSPs

Máté Lengyel, Ádám Kepecs, P. Érdi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recent experimental evidence suggests that inhibitory synapses are associated with different actions depending upon their location (Miles et al., Neuron 16 (1996) 815-823). We investigated that question of whether this effect is due to different subspecies of GABA(A) receptors giving rise to distinct responses (Pearce, Neuron 10 (1993) 189-20) or cable filtering by the dendritic tree. The effects of electrotonic filtering on GABA(A) receptor mediated IPSPs were studied in hippocampal pyramidal cells. We implemented two models with different morphologies where these differences could be explained by electrotonic filtering alone. Our parameter search resulted in realistic passive cell models where the dependence of electrotonic attenuation on morphological distance agreed with that seen in reconstructed cells.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalNeurocomputing
Volume26-27
DOIs
Publication statusPublished - Jun 1999

Fingerprint

Inhibitory Postsynaptic Potentials
GABA-A Receptors
Neurons
Pyramidal Cells
Synapses
Cables

Keywords

  • Cable filtering
  • Inhibition
  • Multi-compartmental methods

ASJC Scopus subject areas

  • Artificial Intelligence
  • Cellular and Molecular Neuroscience

Cite this

Location-dependent differences between somatic and dendritic IPSPs. / Lengyel, Máté; Kepecs, Ádám; Érdi, P.

In: Neurocomputing, Vol. 26-27, 06.1999, p. 193-197.

Research output: Contribution to journalArticle

Lengyel, Máté ; Kepecs, Ádám ; Érdi, P. / Location-dependent differences between somatic and dendritic IPSPs. In: Neurocomputing. 1999 ; Vol. 26-27. pp. 193-197.
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