Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary

P. Fuszek, Henrik Csaba Horvath, G. Speer, J. Papp, Petra Haller, S. Fischer, J. Halász, Balazs Jaray, Eszter Szekely, Z. Schaff, Andras Papp, Attila Bursics, Laszlo Harsanyi, Peter Lukovich, P. Kupcsulik, E. Hitre, P. Lakatos

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: In recent decades, the incidence of proximal colorectal cancer (CRC) in North America and Western Europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients. Patients and Methods: The clinical and histological data of 1694 CRC patients (MIF: 917/777, age at diagnosis: 65.2±SD 12.5 years), diagnosed at the First Department of Medicine and the First Department of Surgery of Semmelweis University, Budapest, Hungary, between January 1, 1993 and December 31, 2004, were analyzed retrospectively. Results: CRCs were rectal or left-sided in 70% and proximal (transverse, ascending or cecum) in 30% of the cases. The proportion of rectal carcinomas increased over the observed period (1993-1998: 31.6% vs. 1999-2004: 42.1%, p=0.001), while the proportion of proximal tumors remained stable. Eleven percent of CRCs were diagnosed under the age of 50 years. The age at diagnosis did not differ between males and females, but was lower in patients with rectal tumors compared to other localizations (p=0.02); 75.7% of the CRCs were T3-T4 at diagnosis and lymph node metastases could be detected in 47.7%. Conclusion: In contrast to Western European and North American trends, the proportion of proximal CRCs did not increase in Hungary over the observed period. Almost two-thirds of all cancers were left-sided. The high percentage of locally advanced tumors and lymph node metastases supports the need for colorectal screening programs.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalAnticancer Research
Volume26
Issue number1 B
Publication statusPublished - Jan 2006

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Hungary
Early Detection of Cancer
Age of Onset
Colorectal Neoplasms
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Cecum
Rectal Neoplasms
North America
Medicine
Carcinoma
Incidence

Keywords

  • Cancer screening
  • Colorectal cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary. / Fuszek, P.; Horvath, Henrik Csaba; Speer, G.; Papp, J.; Haller, Petra; Fischer, S.; Halász, J.; Jaray, Balazs; Szekely, Eszter; Schaff, Z.; Papp, Andras; Bursics, Attila; Harsanyi, Laszlo; Lukovich, Peter; Kupcsulik, P.; Hitre, E.; Lakatos, P.

In: Anticancer Research, Vol. 26, No. 1 B, 01.2006, p. 527-531.

Research output: Contribution to journalArticle

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title = "Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary",
abstract = "Background: In recent decades, the incidence of proximal colorectal cancer (CRC) in North America and Western Europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients. Patients and Methods: The clinical and histological data of 1694 CRC patients (MIF: 917/777, age at diagnosis: 65.2±SD 12.5 years), diagnosed at the First Department of Medicine and the First Department of Surgery of Semmelweis University, Budapest, Hungary, between January 1, 1993 and December 31, 2004, were analyzed retrospectively. Results: CRCs were rectal or left-sided in 70{\%} and proximal (transverse, ascending or cecum) in 30{\%} of the cases. The proportion of rectal carcinomas increased over the observed period (1993-1998: 31.6{\%} vs. 1999-2004: 42.1{\%}, p=0.001), while the proportion of proximal tumors remained stable. Eleven percent of CRCs were diagnosed under the age of 50 years. The age at diagnosis did not differ between males and females, but was lower in patients with rectal tumors compared to other localizations (p=0.02); 75.7{\%} of the CRCs were T3-T4 at diagnosis and lymph node metastases could be detected in 47.7{\%}. Conclusion: In contrast to Western European and North American trends, the proportion of proximal CRCs did not increase in Hungary over the observed period. Almost two-thirds of all cancers were left-sided. The high percentage of locally advanced tumors and lymph node metastases supports the need for colorectal screening programs.",
keywords = "Cancer screening, Colorectal cancer",
author = "P. Fuszek and Horvath, {Henrik Csaba} and G. Speer and J. Papp and Petra Haller and S. Fischer and J. Hal{\'a}sz and Balazs Jaray and Eszter Szekely and Z. Schaff and Andras Papp and Attila Bursics and Laszlo Harsanyi and Peter Lukovich and P. Kupcsulik and E. Hitre and P. Lakatos",
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T1 - Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary

AU - Fuszek, P.

AU - Horvath, Henrik Csaba

AU - Speer, G.

AU - Papp, J.

AU - Haller, Petra

AU - Fischer, S.

AU - Halász, J.

AU - Jaray, Balazs

AU - Szekely, Eszter

AU - Schaff, Z.

AU - Papp, Andras

AU - Bursics, Attila

AU - Harsanyi, Laszlo

AU - Lukovich, Peter

AU - Kupcsulik, P.

AU - Hitre, E.

AU - Lakatos, P.

PY - 2006/1

Y1 - 2006/1

N2 - Background: In recent decades, the incidence of proximal colorectal cancer (CRC) in North America and Western Europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients. Patients and Methods: The clinical and histological data of 1694 CRC patients (MIF: 917/777, age at diagnosis: 65.2±SD 12.5 years), diagnosed at the First Department of Medicine and the First Department of Surgery of Semmelweis University, Budapest, Hungary, between January 1, 1993 and December 31, 2004, were analyzed retrospectively. Results: CRCs were rectal or left-sided in 70% and proximal (transverse, ascending or cecum) in 30% of the cases. The proportion of rectal carcinomas increased over the observed period (1993-1998: 31.6% vs. 1999-2004: 42.1%, p=0.001), while the proportion of proximal tumors remained stable. Eleven percent of CRCs were diagnosed under the age of 50 years. The age at diagnosis did not differ between males and females, but was lower in patients with rectal tumors compared to other localizations (p=0.02); 75.7% of the CRCs were T3-T4 at diagnosis and lymph node metastases could be detected in 47.7%. Conclusion: In contrast to Western European and North American trends, the proportion of proximal CRCs did not increase in Hungary over the observed period. Almost two-thirds of all cancers were left-sided. The high percentage of locally advanced tumors and lymph node metastases supports the need for colorectal screening programs.

AB - Background: In recent decades, the incidence of proximal colorectal cancer (CRC) in North America and Western Europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients. Patients and Methods: The clinical and histological data of 1694 CRC patients (MIF: 917/777, age at diagnosis: 65.2±SD 12.5 years), diagnosed at the First Department of Medicine and the First Department of Surgery of Semmelweis University, Budapest, Hungary, between January 1, 1993 and December 31, 2004, were analyzed retrospectively. Results: CRCs were rectal or left-sided in 70% and proximal (transverse, ascending or cecum) in 30% of the cases. The proportion of rectal carcinomas increased over the observed period (1993-1998: 31.6% vs. 1999-2004: 42.1%, p=0.001), while the proportion of proximal tumors remained stable. Eleven percent of CRCs were diagnosed under the age of 50 years. The age at diagnosis did not differ between males and females, but was lower in patients with rectal tumors compared to other localizations (p=0.02); 75.7% of the CRCs were T3-T4 at diagnosis and lymph node metastases could be detected in 47.7%. Conclusion: In contrast to Western European and North American trends, the proportion of proximal CRCs did not increase in Hungary over the observed period. Almost two-thirds of all cancers were left-sided. The high percentage of locally advanced tumors and lymph node metastases supports the need for colorectal screening programs.

KW - Cancer screening

KW - Colorectal cancer

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M3 - Article

VL - 26

SP - 527

EP - 531

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

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