Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study

Gabriella Moldrich, T. Wenger

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

The presence of central cannabinoid receptor (CB1), involving the N-terminal 14 amino acid peptide, was demonstrated in the rat brain by immunohistochemistry. Intensely stained neurons were observed in the principal neurons of the hippocampus, striatum, substantia nigra, cerebellar cortex, including the Purkinje cells. Moderate CB1-IR cell bodies and fibers were present in the olfactory bulb, cingulate, entorhinal and piriform cortical areas, amygdala and nucleus accumbens. The perivascular glial fibers have shown moderate to high density CB1-IR in olfactoric and limbic structures. Low density was detected in the thalamus and hypothalamus and area postrema. The CB1 receptor was widely distributed in the forebrain and sparsely in the hindbrain. These new data support the view that the endogenous cannabinoids play an important role in different neuronal functions as neuromodulators or neurotrasmitters. (C) 2000 Published by Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1735-1742
Number of pages8
JournalPeptides
Volume21
Issue number11
DOIs
Publication statusPublished - 2000

Fingerprint

Cannabinoid Receptor CB1
Neurons
Rats
Brain
Area Postrema
Rhombencephalon
Cerebellar Cortex
Cannabinoids
Fibers
Olfactory Bulb
Purkinje Cells
Nucleus Accumbens
Substantia Nigra
Prosencephalon
Thalamus
Neuroglia
Hypothalamus
Neurotransmitter Agents
Hippocampus
Immunohistochemistry

Keywords

  • Cerebellum
  • Endogenous cannabinoid
  • Limbic system
  • Olfactory system

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study. / Moldrich, Gabriella; Wenger, T.

In: Peptides, Vol. 21, No. 11, 2000, p. 1735-1742.

Research output: Contribution to journalArticle

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