Localization of targets for anti-ulcer drugs in cells of the immune system

Éva Mezey, M. Palkóvits

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The gastric mucosa consists of the epithelium, which lines the lumen, the lamina propria, and the muscularis mucosae. The targets of drugs used to treat stomach and duodenal ulcers are thought to be the acid-secreting parietal cells of the epithelium. However, immune cells in the lamina propria are the only cells that showed detectable messenger RNAs for histamine, muscarinic, gastrin, and dopamine receptors by in situ hybridization histochemistry. None of the epithelial cells expressed any of these messenger RNAs. Thus, the targets of antiulcer drugs seem to be cells of the immune system in the gut and not parietal cells, as generally believed. This conclusion may revise the thinking about ulcer formation and may shed light on the etiology of such chronic small intestinal diseases as Crohn's disease.

Original languageEnglish
Pages (from-to)1662-1665
Number of pages4
JournalScience
Volume258
Issue number5088
Publication statusPublished - Dec 4 1992

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Anti-Ulcer Agents
Immune System
Mucous Membrane
Epithelium
Cholecystokinin B Receptor
Histamine Receptors
Intestinal Diseases
Messenger RNA
Dopamine Receptors
Muscarinic Receptors
Stomach Ulcer
Duodenal Ulcer
Gastric Mucosa
Crohn Disease
Pharmaceutical Preparations
Ulcer
In Situ Hybridization
Epithelial Cells
Acids

ASJC Scopus subject areas

  • General

Cite this

Localization of targets for anti-ulcer drugs in cells of the immune system. / Mezey, Éva; Palkóvits, M.

In: Science, Vol. 258, No. 5088, 04.12.1992, p. 1662-1665.

Research output: Contribution to journalArticle

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