Localization of single-cell current sources based on extracellular potential patterns

The spike CSD method

Zoltán Somogyvári, Dorottya Cserpán, I. Ulbert, P. Érdi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Traditional current source density (tCSD) calculation method calculates neural current source distribution of extracellular (EC) potential patterns, thus providing important neurophysiological information. While the tCSD method is based on physical principles, it adopts some assumptions, which can not hold for single-cell activity. Consequently, tCSD method gives false results for single-cell activity. A new, spike CSD (sCSD) method has been developed, specifically designed to reveal CSD distribution of single cells during action potential generation. This method is based on the inverse solution of the Poisson-equation. The efficiency of the method is tested and demonstrated with simulations, and showed, that the sCSD method reconstructed the original CSD more precisely than the tCSD. The sCSD method is applied to EC spatial potential patterns of spikes, measured in cat primary auditory cortex with a 16-channel chronically implanted linear probe in vivo. Using our method, the cell-electrode distances were estimated and the spatio-temporal CSD distributions were reconstructed. The results suggested, that the new method is potentially useful in determining fine details of the spatio-temporal dynamics of spikes.

Original languageEnglish
Pages (from-to)3299-3313
Number of pages15
JournalEuropean Journal of Neuroscience
Volume36
Issue number10
DOIs
Publication statusPublished - Nov 2012

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Action Potentials
Auditory Cortex
Electrodes
Cats

Keywords

  • Action potential back-propagation
  • Auditory cortex
  • Cat
  • Current source density
  • Dendritic forward propagation
  • Ranvier-nodes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Localization of single-cell current sources based on extracellular potential patterns : The spike CSD method. / Somogyvári, Zoltán; Cserpán, Dorottya; Ulbert, I.; Érdi, P.

In: European Journal of Neuroscience, Vol. 36, No. 10, 11.2012, p. 3299-3313.

Research output: Contribution to journalArticle

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